Cell Models to Study Regulation of Cell Transformation in Pathologies of Retinal Pigment Epithelium

Table 1

Human RPE cell lines (according to Mannermaa [31], modified).

Cell line	Source	References
Spontaneously transformed cell lines
H80HrPE-6	Created by Goro Eguchi using primary RPE cells from an 80-year-old person	Tsonis et al. [32]
ARPE-19	Derived in 1986 by Amy Aotaki-Keen from the normal eyes of a 19-year-old male who died from head trauma in a motor vehicle accident	Dunn et al. [33]; ATCC CRL-2302
D407	Derived from the eye of a 12-year-old male child	Davis et al. [34]
RPE-340	Derived in 1989 from the eye of a 1-year-old female child who died from trauma	Matsunaga et al. [35]; Rambhatla et al. [36]
Immortalized cell lines
hTERT RPE-1	Generated by transfecting the RPE-340 cell line with a plasmid expressing the human telomerase reverse transcriptase subunit (hTERT)	Rambhatla et al. [36],; ATCC CRL-4000
h1RPE-7; h1RPE-116	Generated by transfecting primary RPE cells from a 50-year-old female donor with a plasmid encoding the SV40 large T antigen	Lund et al. [37]; Kanuga et al. [38]