Journal of Ophthalmology / 2014 / Article / Tab 1

Review Article

Cell Models to Study Regulation of Cell Transformation in Pathologies of Retinal Pigment Epithelium

Table 1

Human RPE cell lines (according to Mannermaa [31], modified).

Cell lineSourceReferences

Spontaneously transformed cell lines
H80HrPE-6Created by Goro Eguchi using primary RPE cells from an 80-year-old person Tsonis et al. [32]
ARPE-19 Derived in 1986 by Amy Aotaki-Keen from the normal eyes of a 19-year-old male who died from head trauma in a motor vehicle accidentDunn et al. [33];  
D407Derived from the eye of a 12-year-old male childDavis et al. [34]
RPE-340Derived in 1989 from the eye of a 1-year-old female child who died from trauma Matsunaga et al. [35];  
Rambhatla et al. [36]

Immortalized cell lines
hTERT RPE-1Generated by transfecting the RPE-340 cell line with a plasmid expressing the human telomerase reverse transcriptase subunit (hTERT)Rambhatla et al. [36],  
Generated by transfecting primary RPE cells from a 50-year-old female donor with a plasmid encoding the SV40 large T antigenLund et al. [37]  
Kanuga et al. [38]