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Journal of Ophthalmology
Volume 2014, Article ID 820710, 8 pages
http://dx.doi.org/10.1155/2014/820710
Review Article

Gender Differences in Behçet’s Disease Associated Uveitis

1National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
2Ophthalmology Department, Cerrahpasa Medical Faculty, Istanbul University, 34080 Istanbul, Turkey
3College of Medicine, University of South Alabama, Mobile, AL 36688, USA

Received 8 October 2013; Revised 20 March 2014; Accepted 20 March 2014; Published 23 April 2014

Academic Editor: Debra Goldstein

Copyright © 2014 Didar Ucar-Comlekoglu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Gül, “Behçet's disease: an update on the pathogenesis,” Clinical and Experimental Rheumatology, vol. 19, no. 5, supplement 24, pp. S6–S12, 2001. View at Google Scholar
  2. E. F. Remmers, F. Cosan, Y. Kirino et al., “Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease,” Nature Genetics, vol. 42, no. 8, pp. 698–702, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. D. McGonagle and M. F. McDermott, “A proposed classification of the immunological diseases,” PLoS Medicine, vol. 3, no. 8, article e297, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Yazici, I. Fresko, and S. Yurdakul, “Behçet's syndrome: disease manifestations, management, and advances in treatment,” Nature Reviews Rheumatology, vol. 3, no. 3, pp. 148–155, 2007. View at Publisher · View at Google Scholar
  5. Y. Kirino, Q. Zhou, Y. Ishigatsubo et al., “Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behçet disease,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 20, pp. 8134–8139, 2013. View at Publisher · View at Google Scholar
  6. P. Fietta, “Behçet's disease: familial clustering and immunogenetics,” Clinical and Experimental Rheumatology, vol. 23, no. 4, supplement 38, pp. S96–S105, 2005. View at Google Scholar
  7. H. Yazici, S. Yurdakul, V. Hamuryudan, and I. Fresko, “Behçet’s syndrome,” in Rheumatology, M. C. Hochberg, J. A. Silman, J. S. Smolen, M. E. Weinblatt, and M. H. Weisman, Eds., pp. 1665–1669, Mosby, London, UK, 3rd edition, 2003. View at Google Scholar
  8. T. Saylan, G. Ozarmagan, G. Azizlerli, C. Ovül, and N. Oke, “Behçet disease in Turkey,” Zeitschrift für Hautkrankheiten, vol. 61, no. 15, pp. 1120–1122, 1986. View at Google Scholar
  9. A. Gürler, A. Boyvat, and U. Türsen, “Clinical manifestations of Behçet's disease: an analysis of 2147 patients,” Yonsei Medical Journal, vol. 38, no. 6, pp. 423–427, 1997. View at Google Scholar
  10. C. H. C. Zouboulis, D. Djawari, and W. Kirch, “Adamantiades-Behçet's disease in Germany,” in Behçet's Disease, P. Godeau and B. Wechsler, Eds., pp. 193–196, Elsevier Science, Amsterdam, The Netherlands, 1st edition, 1993. View at Google Scholar
  11. L. C. See, C. F. Kuo, I. J. Chou, M. J. Chiou, and K. H. Yu, “Sex- and age-specific incidence of autoimmune rheumatic diseases in the Chinese population: a Taiwan population-based study,” Seminars in Arthritis and Rheumatism, vol. 43, no. 3, pp. 381–386, 2013. View at Publisher · View at Google Scholar
  12. F. Davatchi, F. Shahram, C. Chams-Davatchi et al., “Behçet's disease: from east to west,” Clinical Rheumatology, vol. 29, no. 8, pp. 823–833, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Gül, “Behçet's disease as an autoinflammatory disorder,” Current Drug Targets: Inflammation & Allergy, vol. 4, no. 1, pp. 81–83, 2005. View at Publisher · View at Google Scholar
  14. International Study Group for Behçet's Disease, “Criteria for diagnosis of Behçet's disease,” The Lancet, vol. 335, no. 8697, pp. 1078–1080, 1990. View at Publisher · View at Google Scholar
  15. E. Alpsoy, C. C. Zouboulis, and G. E. Ehrlich, “Mucocutaneous lesions of Behçet's disease,” Yonsei Medical Journal, vol. 48, no. 4, pp. 573–585, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. E. Alpsoy, L. Donmez, M. Onder et al., “Clinical features and natural course of Behçet's disease in 661 cases: a multicentre study,” British Journal of Dermatology, vol. 157, no. 5, pp. 901–906, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Yazici, Y. Tüzün, H. Pazarli et al., “Influence of age of onset and patient's sex on the prevalence and severity of manifestations of Behçet's syndrome,” Annals of the Rheumatic Diseases, vol. 43, no. 6, pp. 783–789, 1984. View at Publisher · View at Google Scholar
  18. E. C. Ebert, “Gastrointestinal manifestations of Behçet's disease,” Digestive Diseases and Sciences, vol. 54, no. 2, pp. 201–207, 2009. View at Publisher · View at Google Scholar
  19. L. Y. Wang, D. B. Zhao, J. Gu, and S. M. Dai, “Clinical characteristics of Behçet's disease in China,” Rheumatology International, vol. 30, no. 9, pp. 1191–1196, 2010. View at Publisher · View at Google Scholar
  20. F. Shahram, F. Davatchi, A. Nadji et al., “Recent epidemiological data on Behçet's disease in Iran. The 2001 survey,” Advances in Experimental Medicine and Biology, vol. 528, pp. 31–36, 2003. View at Google Scholar · View at Scopus
  21. S. H. Oh, E. C. Han, J. H. Lee, and D. Bang, “Comparison of the clinical features of recurrent aphthous stomatitis and Behçet's disease,” Clinical and Experimental Dermatology, vol. 34, no. 6, pp. e208–e212, 2009. View at Publisher · View at Google Scholar
  22. I. Koné-Paut, S. Yurdakul, S. A. Bahabri et al., “Clinical features of Behçet's disease in children: an international collaborative study of 86 cases,” The Journal of Pediatrics, vol. 132, no. 4, pp. 721–725, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Davatchi, F. Shahram, C. Chams-Davatchi et al., “Behcet's disease: is there a gender influence on clinical manifestations?” International Journal of Rheumatic Diseases, vol. 15, no. 3, pp. 306–314, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Ideguchi, A. Suda, M. Takeno, A. Ueda, S. Ohno, and Y. Ishigatsubo, “Behçet disease: evolution of clinical manifestations,” Medicine, vol. 90, no. 2, pp. 125–132, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. U. Tursen, A. Gurler, and A. Boyvat, “Evaluation of clinical findings according to sex in 2313 Turkish patients with Behçet's disease,” International Journal of Dermatology, vol. 42, no. 5, pp. 346–351, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Prokaeva, W. Madanat, N. Yermakova, and Z. Alekberova, “Sex dimorphism of Behçet’s disease,” in Behçet’s Disease, P. Godeau and B. Wechsler, Eds., pp. 219–221, Elsevier Science, Amsterdam, The Netherlands, 1993. View at Google Scholar
  27. T. W. O’Neill, A. S. Rigby, S. McHugh, A. Silman, and C. Barnes, “Regional differences in clinical manifestations of Behçet’s disease,” in Behçet’s Disease, P. Godeau and B. Wechsler, Eds., pp. 159–163, Elsevier Science, Amsterdam, The Netherlands, 1993. View at Google Scholar
  28. C. Evereklioglu, “The migration pattern, patient selection with diagnostic methodological flaw and confusing naming dilemma in Behçet disease,” European Journal of Echocardiography, vol. 8, no. 3, pp. 167–174, 2007. View at Google Scholar · View at Scopus
  29. M. Khairallah, M. Accorinti, C. Muccioli, R. Kahloun, and J. H. Kempen, “Epidemiology of Behçet disease,” Ocular Immunology and Inflammation, vol. 20, no. 5, pp. 324–335, 2012. View at Publisher · View at Google Scholar
  30. C. C. Zouboulis, “Epidemiology of Adamantiades-Behçet's disease,” Annales de Médecine Interne, vol. 150, no. 6, pp. 488–498, 1999. View at Google Scholar
  31. K. Nakae, F. Masaki, T. Hashimoto, G. Inaba, M. Mochizuki, and T. Sakane, “Recent epidemiological features of Behçet’s disease in Japan,” in Behçet’s Disease, B. Wechsler and P. Godeau, Eds., pp. 145–151, Excerpta Medica, Amsterdam, The Netherlands, 1993. View at Google Scholar
  32. S. Yurdakul and H. Yazici, “Behçet's syndrome,” Best Practice & Research Clinical Rheumatology, vol. 22, no. 5, pp. 793–809, 2008. View at Publisher · View at Google Scholar
  33. D. Bang, J. H. Lee, E.-S. Lee et al., “Epidemiologic and clinical survey of Behçet's disease in Korea: the first multicenter study,” Journal of Korean Medical Science, vol. 16, no. 5, pp. 615–618, 2001. View at Google Scholar · View at Scopus
  34. S. R. Dalvi, R. Yildirim, and Y. Yazici, “Behçet's Syndrome,” Drugs, vol. 72, no. 17, pp. 2223–2241, 2012. View at Google Scholar
  35. A. Hamzaoui, R. Klii, O. Harzallah, C. Attig, and S. Mahjoub, “Behçet's disease in women,” La Revue de Médecine Interne, vol. 33, no. 10, pp. 552–555, 2012. View at Publisher · View at Google Scholar
  36. T. Sakane, M. Takeno, N. Suzuki, and G. Inaba, “Behçet's disease,” The New England Journal of Medicine, vol. 341, no. 17, pp. 1284–1291, 1999. View at Google Scholar
  37. M. Zierhut, N. Mizuki, S. Ohno et al., “Immunology and functional genomics of Behçet's disease,” Cellular and Molecular Life Sciences, vol. 60, no. 9, pp. 1903–1922, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. J. T. Lie, “Vascular involvement in Behçet's disease: arterial and venous and vessels of all sizes,” The Journal of Rheumatology, vol. 19, no. 3, pp. 341–343, 1992. View at Google Scholar · View at Scopus
  39. Y. Koç, I. Güllü, G. Akpek et al., “Vascular involvement in Behçet's disease,” The Journal of Rheumatology, vol. 19, no. 3, pp. 402–410, 1992. View at Google Scholar · View at Scopus
  40. A. N. Al-Dalaan, S. R. Al Balaa, K. El Ramahi et al., “Behçet's disease in Saudi Arabia,” The Journal of Rheumatology, vol. 21, no. 4, pp. 658–661, 1994. View at Google Scholar · View at Scopus
  41. H. de Jesus, M. Rosa, and M. V. Queiroz, “Vascular involvement in Behçet's disease. An analysis of twelve cases,” Clinical Rheumatology, vol. 16, no. 2, pp. 220–221, 1997. View at Google Scholar · View at Scopus
  42. A. Nadji, F. Shahram, and F. Davatchi, “Vascular involvement in Behçet’s disease: report of 323 cases,” in Proceedings of the 8th International Congress on Behcet’s Disease, vol. 194 of Program and Abstracts, p. 194, Prex, Milano, Italy, 1998.
  43. A. Muftuoglu, S. Yurdakul, H. Yazici et al., “Vascular involvement in Behçet’s disease—a review of 129 cases,” in Recent Advances in Behçet’s Disease, T. Lehner and C. G. Barnes, Eds., vol. 103 of International Congress and Symposium Series, pp. 255–260, Royal Society of Medicine Services, London, UK, 1986. View at Google Scholar
  44. F. Ildan, A. I. Göçer, H. Bağdatoğlu, M. Tuna, and A. Karadayi, “Intracranial arterial aneurysm complicating Behçet's disease,” Neurosurgical Review, vol. 19, no. 1, pp. 53–56, 1996. View at Publisher · View at Google Scholar
  45. S. Nakasu, M. Kaneko, and M. Matsuda, “Cerebral aneurysms associated with Behçet's disease: a case report,” Journal of Neurology Neurosurgery & Psychiatry, vol. 70, no. 5, pp. 682–684, 2001. View at Publisher · View at Google Scholar · View at Scopus
  46. G. Akman-Demir, P. Serdaroglu, and B. Tasçi, “Clinical patterns of neurological involvement in Behçet's disease: evaluation of 200 patients,” Brain, vol. 122, part 11, pp. 2171–2182, 1999. View at Publisher · View at Google Scholar
  47. E. Kural-Seyahi, I. Fresko, N. Seyahi et al., “The long-term mortality and morbidity of Behçet syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center,” Medicine, vol. 82, no. 1, pp. 60–76, 2003. View at Publisher · View at Google Scholar · View at Scopus
  48. M. H. Houman, S. Bellakhal, T. B. Salem et al., “Characteristics of neurological manifestations of Behçet's disease: a retrospective monocentric study in Tunisia,” Clinical Neurology and Neurosurgery, vol. 115, no. 10, pp. 2015–2018, 2013. View at Publisher · View at Google Scholar
  49. R. Talarico, A. d'Ascanio, M. Figus et al., “Behçet's disease: features of neurological involvement in a dedicated centre in Italy,” Clinical and Experimental Rheumatology, vol. 30, no. 3, supplement 72, pp. S69–S72, 2012. View at Google Scholar
  50. A. Al-Araji, K. Sharquie, and Z. Al-Rawi, “Prevalence and patterns of neurological involvement in Behçet's disease: a prospective study from Iraq,” Journal of Neurology Neurosurgery & Psychiatry, vol. 74, no. 5, pp. 608–613, 2003. View at Publisher · View at Google Scholar · View at Scopus
  51. A. Al-Araji and D. P. Kidd, “Neuro-Behçet's disease: epidemiology, clinical characteristics, and management,” The Lancet Neurology, vol. 8, no. 2, pp. 192–204, 2009. View at Publisher · View at Google Scholar · View at Scopus
  52. D. Uluduz, M. Kürtüncü, Z. Yapıcı et al., “Clinical characteristics of pediatric-onset neuro-Behçet disease,” Neurology, vol. 77, no. 21, pp. 1900–1905, 2011. View at Publisher · View at Google Scholar
  53. U. Korman, M. Cantasdemir, S. Kurugoglu et al., “Enteroclysis findings of intestinal Behçet disease: a comparative study with Crohn disease,” Abdominal Imaging, vol. 28, no. 3, pp. 308–312, 2003. View at Publisher · View at Google Scholar · View at Scopus
  54. S. Yurdakul, N. Tüzüner, I. Yurdakul, V. Hamuryudan, and H. Yazici, “Gastrointestinal involvement in Behçet's syndrome: a controlled study,” Annals of the Rheumatic Diseases, vol. 55, no. 3, pp. 208–210, 1996. View at Publisher · View at Google Scholar
  55. I. Kötter, H. Dürk, G. Fieribeck, U. Pleyer, M. Zierhut, and J. G. Saal, “Behçet’s disease in 39 German and Mediterranean patients,” in Behçet’s Disease, P. Godeau and B. Wechsler, Eds., pp. 197–200, Elsevier Science, Amsterdam, The Netherlands, 1993. View at Google Scholar
  56. J. H. Cheon, D. S. Han, J. Y. Park et al., “Development, validation, and responsiveness of a novel disease activity index for intestinal Behcet's disease,” Inflammatory Bowel Diseases, vol. 17, no. 2, pp. 605–613, 2011. View at Publisher · View at Google Scholar · View at Scopus
  57. P. Yang, W. Fang, Q. Meng, Y. Ren, L. Xing, and A. Kijlstra, “Clinical features of chinese patients with Behçet's disease,” Ophthalmology, vol. 115, no. 2, pp. 312.e4–318.e4, 2008. View at Publisher · View at Google Scholar · View at Scopus
  58. I. Tugal-Tutkun, “Behçet's uveitis,” Middle East African Journal of Ophthalmology, vol. 16, no. 4, pp. 219–224, 2009. View at Google Scholar
  59. C. Evereklioglu, “Current concepts in the etiology and treatment of Behçet disease,” Survey of Ophthalmology, vol. 50, no. 4, pp. 297–350, 2005. View at Publisher · View at Google Scholar
  60. A. Ramsay and S. Lightman, “Hypopyon uveitis,” Survey of Ophthalmology, vol. 46, no. 1, pp. 1–18, 2001. View at Publisher · View at Google Scholar · View at Scopus
  61. I. Tugal-Tutkun, S. Onal, R. Altan-Yaycioglu, H. Huseyin Altunbas, and M. Urgancioglu, “Uveitis in Behçet disease: an analysis of 880 patients,” American Journal of Ophthalmology, vol. 138, no. 3, pp. 373–380, 2004. View at Publisher · View at Google Scholar · View at Scopus
  62. T. Fujikado and K. Imagawa, “Dural sinus thrombosis in Behçet's disease—a case report,” Japanese Journal of Ophthalmology, vol. 38, no. 4, pp. 411–416, 1994. View at Google Scholar · View at Scopus
  63. D. H. Verity, J. E. Marr, S. Ohno, G. R. Wallace, and M. R. Stanford, “Behçet's disease, the Silk Road and HLA-B51: historical and geographical perspectives,” Tissue Antigens, vol. 54, no. 3, pp. 213–220, 1999. View at Publisher · View at Google Scholar · View at Scopus
  64. C. Mat, S. Yurdakul, S. Uysal et al., “A double-blind trial of depot corticosteroids in Behçet's syndrome,” Rheumatology, vol. 45, no. 3, pp. 348–352, 2006. View at Publisher · View at Google Scholar · View at Scopus
  65. S. Yurdakul, C. Mat, Y. Tüzün et al., “A double-blind trial of colchicine in Behçet's syndrome,” Arthritis & Rheumatism, vol. 44, no. 11, pp. 2686–2692, 2001. View at Google Scholar
  66. V. Hamuryudan, C. Mat, S. Saip et al., “Thalidomide in the treatment of the mucocutaneous lesions of the Behçet syndrome: a randomized, double-blind, placebo-controlled trial,” Annals of Internal Medicine, vol. 128, no. 6, pp. 443–450, 1998. View at Google Scholar · View at Scopus
  67. H. Yazici, H. Pazarli, C. G. Barnes et al., “A controlled trial of azathioprine in Behçet's syndrome,” The New England Journal of Medicine, vol. 322, no. 5, pp. 281–285, 1990. View at Google Scholar · View at Scopus
  68. K. Masuda, A. Nakajima, A. Urayama, K. Nakae, M. Kogure, and G. Inaba, “Double-masked trial of cyclosporin versus colchicine and long-term open study of cyclosporin in Behçet's disease,” The Lancet, vol. 1, no. 8647, pp. 1093–1096, 1989. View at Google Scholar · View at Scopus
  69. G. Akmar-Demir, O. Ayranci, M. Kurtuncu, E. N. Vanli, M. Mutlu, and I. Tugal-Tutkun, “Cyclosporine for Behçet's uveitis: is it associated with an increased risk of neurological involvement?” Clinical and Experimental Rheumatology, vol. 26, no. 4, supplement 50, pp. S84–S90, 2008. View at Google Scholar · View at Scopus
  70. E. Seyahi and H. Yazici, “Prognosis in Behçet’s syndrome,” in Behçet’s Syndrome, Y. Yazici and H. Yazici, Eds., pp. 285–295, Springer, New York, NY, USA, 2010. View at Google Scholar
  71. H. T. Özer, R. Günesaçar, S. Dinkçi, Z. Özbalkan, F. Yildiz, and E. Erken, “The impact of smoking on clinical features of Behçet's disease patients with glutathione S-transferase polymorphisms,” Clinical and Experimental Rheumatology, vol. 30, no. 3, supplement 72, pp. S14–S17, 2012. View at Google Scholar
  72. S. W. Rizvi and H. McGrath Jr., “The therapeutic effect of cigarette smoking on oral/genital aphthosis and other manifestations of Behçet's disease,” Clinical and Experimental Rheumatology, vol. 19, no. 5, supplement 24, pp. S77–S78, 2001. View at Google Scholar · View at Scopus
  73. K. Aramaki, H. Kikuchi, and S. Hirohata, “HLA-B51 and cigarette smoking as risk factors for chronic progressive neurological manifestations in Behçet's disease,” Modern Rheumatology, vol. 17, no. 1, pp. 81–82, 2007. View at Publisher · View at Google Scholar · View at Scopus
  74. M. Can, M. Gunes, O. A. Haliloglu et al., “Effect of vitamin D deficiency and replacement on endothelial functions in Behçet's disease,” Clinical and Experimental Rheumatology, vol. 30, no. 3, supplement 72, pp. S57–S61, 2012. View at Google Scholar
  75. K. Hamzaoui, I. B. Dhifallah, E. Karray, F. H. Sassi, and A. Hamzaoui, “Vitamin D modulates peripheral immunity in patients with Behçet's disease,” Clinical and Experimental Rheumatology, vol. 28, no. 4, supplement 60, pp. S50–S57, 2010. View at Google Scholar · View at Scopus
  76. C. Maldini, M. P. Lavalley, M. Cheminant, M. de menthon, and A. Mahr, “Relationships of HLA-B51 or B5 genotype with Behçet's disease clinical characteristics: systematic review and meta-analyses of observational studies,” Rheumatology, vol. 51, no. 5, pp. 887–900, 2012. View at Publisher · View at Google Scholar · View at Scopus
  77. D. Bang, Y. S. Chun, I. B. Haam, E.-S. Lee, and S. Lee, “The Influence of pregnancy on Behçet's disease,” Yonsei Medical Journal, vol. 38, no. 6, pp. 437–443, 1997. View at Google Scholar · View at Scopus