Correlations between ERG, OCT, and Anatomical Findings in the rd10 Mouse

Figure 4

Histological evaluation of HE stained retinae. Pigment epithelium and photoreceptors are displayed to the top. (a) Area of evaluation. The papilla is cut directly through the median. (b) rd10 mouse retina at the age of five weeks (left) in contrast to wild type mouse (right). In rd10 mice, the ONL (yellow bars) was reduced to two layers of somata and the retina separated from the pigment epithelium. In wild type mice, outer segments of the photoreceptors were in contact with the pigment epithelium (same age; ONL = outer nuclear layer, INL = inner nuclear layer, and IPL = inner plexiform layer) (c) HE-staining of the retinae of wild type (first row) and rd10 mice (second row) at the age of 2, 5, 9, 24, and 48 weeks. In rd10 mice, the retinal thickness decreased with age, whereas in wild type mice, no differences in thickness were observed.