TY - JOUR A2 - Groll, Jürgen AU - Pinazo-Durán, Maria D. AU - Gómez-Ulla, Francisco AU - Arias, Luis AU - Araiz, Javier AU - Casaroli-Marano, Ricardo AU - Gallego-Pinazo, Roberto AU - García-Medina, Jose J. AU - López-Gálvez, Maria Isabel AU - Manzanas, Lucía AU - Salas, Anna AU - Zapata, Miguel AU - Diaz-Llopis, Manuel AU - García-Layana, Alfredo PY - 2014 DA - 2014/01/23 TI - Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention? SP - 901686 VL - 2014 AB - Purpose. To review the proposed pathogenic mechanisms of age macular degeneration (AMD), as well as the role of antioxidants (AOX) and omega-3 fatty acids (ω-3) supplements in AMD prevention. Materials and Methods. Current knowledge on the cellular/molecular mechanisms of AMD and the epidemiologic/experimental studies on the effects of AOX and ω-3 were addressed all together with the scientific evidence and the personal opinion of professionals involved in the Retina Group of the OFTARED (Spain). Results. High dietary intakes of ω-3 and macular pigments lutein/zeaxanthin are associated with lower risk of prevalence and incidence in AMD. The Age-Related Eye Disease study (AREDS) showed a beneficial effect of high doses of vitamins C, E, beta-carotene, and zinc/copper in reducing the rate of progression to advanced AMD in patients with intermediate AMD or with one-sided late AMD. The AREDS-2 study has shown that lutein and zeaxanthin may substitute beta-carotene because of its potential relationship with increased lung cancer incidence. Conclusion. Research has proved that elder people with poor diets, especially with low AOX and ω-3 micronutrients intake and subsequently having low plasmatic levels, are more prone to developing AMD. Micronutrient supplementation enhances antioxidant defense and healthy eyes and might prevent/retard/modify AMD. SN - 2090-004X UR - https://doi.org/10.1155/2014/901686 DO - 10.1155/2014/901686 JF - Journal of Ophthalmology PB - Hindawi Publishing Corporation KW - ER -