Journal of Ophthalmology / 2015 / Article / Tab 2

Review Article

An Updated Meta-Analysis: Risk Conferred by Glutathione S-Transferases (GSTM1 and GSTT1) Polymorphisms to Age-Related Cataract

Table 2

Subgroup analysis of the association between GSTM1 and GSTT1 polymorphisms and the risk of age-related cataract.

GroupsNumber of studiesStatistical methodOR (95% CI)References

GSTM1:
 All studies15Random1.161 (0.863–1.563)0.324[1832]
 Ethnicity:
  Asian6Random1.372 (0.786–2.396)0.266[1823]
  Caucasian9Random1.053 (0.726–1.526)0.158[2432]
 Gender:
  Female5Random1.016 (0.444–2.324)0.970[22, 24, 27, 29, 30]
  Male5Random0.892 (0.582–1.365)0.598[22, 24, 27, 29, 30]
 Subtype:
  CC6Fixed0.713 (0.598–0.850)<0.001[21, 22, 2426, 29]
  NC5Fixed0.887 (0.685–1.148)0.363[21, 2426, 29]
  PSC4Fixed1.042 (0.797–1.362)0.765[21, 2426, 29]
  MT3Random0.937 (0.510–1.722)0.834[24, 26, 29]
 Environmental risk factors:
  Outdoor2Fixed1.019 (0.511–2.034)0.957[28, 31]
  Indoor2Random2.062 (1.074–3.961)0.030[28, 31]
GSTT1:
 All studies9Fixed1.229 (1.057–1.429)0.007[21, 22, 24, 26, 27, 2932]
 Ethnicity:
  Asian2Fixed1.442 (1.137–1.830)0.003[21, 22]
  Caucasian7Fixed1.113 (0.830–1.492)0.474 [24, 26, 27, 2932]
 Gender:
  Female5Fixed1.281 (0.972–1.687)0.078[22, 24, 27, 29, 30]
  Male5Fixed1.288 (0.977–1.698)0.073[22, 24, 27, 29, 30]
 Subtype:
  CC5Fixed1.226 (0.999–1.504)0.051[21, 22, 24, 26, 29]
  NC4Random0.921 (0.524–1.617)0.774[21, 24, 26, 29]
  PSC4Fixed1.421 (1.043–1.936)0.026[21, 24, 26, 29]
  MT3Random1.209 (0.663–2.204)0.535[24, 26, 29]
GSTM1 null + GSTT1 null:6Fixed1.069 (0.843–1.356)0.581[22, 24, 26, 27, 29, 30]
GSTM1 positive + GSTT1 positive:6Random1.005 (0.658–1.536)0.981[22, 24, 26, 27, 29, 30]

GSTM1 positive + GSTT1 null:5Random1.281 (0.840–1.954)0.250[22, 24, 27, 29, 30]

GSTM1: glutathione S-transferase M1; GSTT1: glutathione S-transferase T1. CC: cortical cataract; NC: nuclear cataract; PSC: posterior subcapsular cataract; MT: mixed type cataract. Fixed: a fixed effects model (Mantel-Haenszel method); Random: the random effects model (DerSimonian-Laird method).