Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis

Figure 2

Representative photos of each treatment group on days 0, 8, and 15 after implantation of human vascular endothelial growth factor (VEGF) polymer within the corneal stroma micropocket. Treatment drugs were delivered via subconjunctival injection on days 0, 5, 8, 12, and 15. No statistical difference was noted between bevacizumab (BV) and Fc-endostatin 2 mg/mL (FcE 2). BV was found to significantly decrease neovascularization when compared with Fc-endostatin 20 mg/mL (FcE 20) by day 8. FcE 2 was found to significantly decrease neovascularization compared with FcE 20 by day 15.