Effects of Lutein and Zeaxanthin on LPS-Induced Secretion of IL-8 by Uveal Melanocytes and Relevant Signal Pathways

Figure 5

LPS, lutein, and zeaxanthin and various signal pathways. UM were seeded into the culture dishes, treated with LPS with or without previous treatment of lutein or zeaxanthin. p-MAPKs in the cells and NF-κB levels in the cell nuclear extracts were determined by ELISA kit and expressed as percentage of the controls. LPS significantly increased p-JNK (a) and NF-κB levels (d) ( as compared with cells not treated with LPS) but not p-p38 MAPK (c) and p-ERG1/2 levels (d) in cultured UM.

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