Clinical Study
Pharmacological Isolation of Cognitive Components Influencing the Pupillary Light Reflex
Table 1
Summary of pupillary measures [mean (standard deviation)] for placebo, dapiprazole, and tropicamide sessions as a function of task condition.
| | | Placebo | Dapiprazole | Tropicamide | | | (block dilator) | (block sphincter) |
| | Initial diameter (mm) | | | | | No Task | 6.122 (1.121) | 5.268 (1.211) | 7.842 (1.028) | | Add 1 | 6.321 (1.176) | 5.507 (1.215) | 7.836 (0.989) | | Subtract 7 | 6.742 (1.101) | 5.727 (1.068) | 7.912 (0.999) | | Constriction amplitude (mm) | | | | | No Task | 0.956 (0.460) | 0.867 (0.365) | | | Add 1 | 0.903 (0.475) | 0.885 (0.436) | | | Subtract 7 | 0.731 (0.446) | 0.799 (0.409) | | | % Change (constriction/initial diameter × 100) | | | | | No Task | | | | | Add 1 | | | | | Subtract 7 | | | | | Start of constriction (msec) | | | | | No Task | 342.2 (42.5) | 343.4 (38.5) | | | Add 1 | 351.4 (38.7) | 337.2 (36.0) | | | Subtract 7 | 355.1 (38.3) | 345.2 (30.7) | | | End of constriction (msec) | | | | | No Task | 1048.0 (182.4) | 952.0 (152.7) | | | Add 1 | 1018.5 (204.4) | 918.2 (97.8) | | | Subtract 7 | 1099.1 (104.8) | 872.6 (70.9) | | | Latency to 50% recovery of initial diameter (msec) | | | | | No Task | 1872.83 (527.2) | 1788.41 (201.2) | — | | Add 1 | 1703.45 (598.6) | 1690.21 (438.1) | — | | Subtract 7 | 1608.0 (559.3) | 1599.72 (421.3) | — |
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Values obtained from grand means across subjects.
—: no data available as changes too small to assess.
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