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Journal of Ophthalmology
Volume 2015, Article ID 193078, 8 pages
http://dx.doi.org/10.1155/2015/193078
Research Article

Polycystic Ovary Syndrome: Aggressive or Protective Factor for the Retina? Evaluation of Macular Thickness and Retinal Nerve Fiber Layers Using High-Definition Optical Coherence Tomography

1Post-Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil
2Department of Biomedical Sciences, State University of Rio Grande do Norte, Mossoró, RN, Brazil
3Department of Biomedical Sciences, Faculty of Health Sciences, Federal University of Rio Grande do Norte, Central Campus, St. Atirador Miguel Antônio da Silva Neto, s/n, Aeroporto, 59607-360 Mossóro, RN, Brazil
4Department of Surgery, Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, Natal, RN, Brazil
5Department of Obstetrics and Gynecology, Federal University of Rio Grande do Norte, Natal, RN, Brazil
6Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, RN, Brazil
7Department of Morphology, Federal University of Rio Grande do Norte, Natal, RN, Brazil

Received 8 October 2014; Revised 17 January 2015; Accepted 19 January 2015

Academic Editor: Hyeong Gon Yu

Copyright © 2015 José Edvan de Souza-Júnior et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To compare macular thickness (MT) and retinal nerve fiber layers (RNFL) between women with polycystic ovary syndrome (PCOS) and healthy women. Materials and Methods. The study included 45 women with PCOS and 47 ovulatory women undergoing clinical-gynecological and ophthalmic evaluations, including measurement of MT, RNFL, and optic disc parameters using optical coherence tomography. Results. The superior RNFL around the optic nerve was significantly thicker in PCOS than in healthy volunteers (). After stratification according to insulin resistance, the temporal inner macula (TIM), the inferior inner macula (IIM), the nasal inner macula (NIM), and the nasal outer macula (NOM) were significantly thicker in PCOS group than in control group (). Both the presence of obesity associated with insulin resistance () and glucose intolerance () were associated with significant increase in the PC1 mean score, relative to MT. A significant increase in the PC2 mean score occurred when considering the presence of metabolic syndrome (). There was a significant interaction between obesity and inflammation in a decreasing mean PC2 score relative to macular RNFL thickness (). Conclusion. Decreased macular RNFL thickness and increased total MT are associated with metabolic abnormalities, while increased RNFL thickness around the optic nerve is associated with hormonal changes inherent in PCOS.