Effects of Zeaxanthin on Growth and Invasion of Human Uveal Melanoma in Nude Mouse Model

Figure 2

Microscopic photographs of mouse eyes inoculated with human uveal melanoma cells with or without zeaxanthin treatment (original magnification 4). Eyes were enucleated and stained with hematoxylin-eosin in frozen sections. Tumor was marked by red outlines. In the eye not treated with zeaxanthin (control eye), tumor fills large part of the eyeball (a) with scleral perforation and extraocular extension of melanoma (arrow E). Tumor in eye treated with low dosage of zeaxanthin (b) is smaller than that of the control eye. Tumors in eye treated with high dosage of zeaxanthin (c) are much smaller than that of eye treated with low dosage of zeaxanthin and control eye.

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(b)

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