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Journal of Ophthalmology
Volume 2015, Article ID 405234, 6 pages
Review Article

The Role of the Endothelin System in the Vascular Dysregulation Involved in Retinitis Pigmentosa

1Department of Surgical Sciences, Unit of Ophthalmology, Ospedale Maggiore, Bologna, Italy
2Department of Biomedical and Surgical Sciences, Section of Human Physiology, University of Ferrara, 44100 Ferrara, Italy
3Department of Biomedical and Surgical Sciences, Division of Ophthalmology, University of Ferrara, 44100 Ferrara, Italy

Received 23 August 2015; Accepted 18 October 2015

Academic Editor: Suphi Taneri

Copyright © 2015 Francesco Saverio Sorrentino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Retinitis pigmentosa is a clinical and genetic group of inherited retinal disorders characterized by alterations of photoreceptors and retinal pigment epithelium leading to a progressive concentric visual field restriction, which may bring about severe central vision impairment. Haemodynamic studies in patients with retinitis pigmentosa have demonstrated ocular blood flow abnormalities both in retina-choroidal and in retroocular vascular system. Moreover, several investigations have studied the augmentation of endothelin-1 plasma levels systemically in the body and locally in the eye. This might account for vasoconstriction and ischemia, typical in vascular dysregulation syndrome, which can be considered an important factor of reduction of the ocular blood flow in subjects affected by retinitis pigmentosa.