Research Article
Association between Ophthalmic Timolol and Hospitalisation for Bradycardia
Table 3
Sensitivity analyses.
| | Risk periods |
hospitalisations | Person-years | Adjusted rate per 10 years (95% CI) | IRR (95% CI) |
| | Exposed patients only (adjusting for age, calendar year, and other conditionsa) | | Unexposed | 161 | 1112 | 1.45 (1.20–1.75) | 1.00 (1.00-1.00) | | Before 1–30 days | 2 | 22 | 0.86 (0.21–3.46) | 0.59 (0.15–2.41) | | After 1–30 days | 25 | 127 | 2.02 (1.32–3.10) | 1.40 (0.86–2.26) | | After 31–180 days | 58 | 234 | 2.78 (2.02–3.81) | 1.91 (1.28–2.85) | | After 180 days | 17 | 121 | 1.75 (0.98–3.13) | 1.21 (0.63–2.30) | | Washout | 4 | 63 | 0.62 (0.23–1.69) | 0.43 (0.16–1.19) |
| | Including unexposed patients (adjusting for age and calendar year) | | Unexposed | 6267 | 36791 | 1.39 (1.33–1.46) | 1.00 (1.00-1.00) | | Before 1–30 days | 2 | 22 | 0.74 (0.18–3.00) | 0.53 (0.13–2.16) | | After 1–30 days | 25 | 127 | 1.77 (1.11–2.82) | 1.27 (0.80–2.02) | | After 31–180 days | 58 | 234 | 2.47 (1.70–3.59) | 1.77 (1.22–2.58) | | After 180 days | 17 | 121 | 1.58 (0.85–2.93) | 1.13 (0.61–2.10) | | Washout | 4 | 63 | 0.54 (0.20–1.48) | 0.39 (0.14–1.06) |
| | Exposed patients only who were dispended at least one oral beta-blocker (adjusting for age and calendar year) | | Unexposed | 97 | 690 | 1.43 (1.11–1.86) | 1.00 (1.00-1.00) | | Before 1–30 days | 2 | 13 | 1.36 (0.34–5.46) | 0.95 (0.23–3.88) | | After 1–30 days | 12 | 81 | 1.54 (0.85–2.80) | 1.08 (0.55–2.09) | | After 31–180 days | 40 | 155 | 2.95 (2.03–4.31) | 2.06 (1.26–3.36) | | After 180 days | 12 | 76 | 2.10 (1.06–4.15) | 1.46 (0.68–3.15) | | Washout | 3 | 39 | 0.77 (0.24–2.43) | 0.54 (0.16–1.75) |
| | Exposed patients only who were not dispended oral beta-blockers (adjusting for age and calendar year) | | Unexposed | 64 | 422 | 1.51 (1.11–2.05) | 1.00 (1.00-1.00) | | Before 1–30 days | 0 | 88 | — | 0.95 (0.23–3.88) | | After 1–30 days | 13 | 46 | 3.04 (1.61–5.73) | 2.01 (0.99–4.08) | | After 31–180 days | 18 | 79 | 2.65 (1.46–4.80) | 1.76 (0.88–3.50) | | After 180 days | 5 | 45 | 1.18 (0.39–3.55) | 0.78 (0.24–2.55) | | Washout | 1 | 24 | 0.42 (0.06–3.05) | 0.28 (0.04–2.06) |
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CI: confidence interval; IRR: incidence rate ratio.
aOral beta-blockers (ATC code C07), calcium-channel blockers (ATC code C08), digitalis glycosides (ATC code C01AA), and antiarrhythmics (ATC code C01B).
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