Assessment of Full-Eye Response to Osmotic Stress in Mouse Model In Vivo Using Optical Coherence Tomography

Table 1

Study procedures of Groups I–IV.

Group	Phase 1	Phase 2	Phase 3
Control	Isotonic (250)
	60 mins, 1/5 times per min
I	Isotonic (250); 10 mins, 1/5 times per min	Hypertonic (1000); 13 mins, 1 time per min	Isotonic (250); 40 mins, 1/5 times per min
II		Hypertonic (500); 13 mins, 1 time per min
III		Hypotonic (100); 24 mins, 1/3 times per min	Isotonic (250); 24 mins, 1/3 times per min
IV		Hypertonic (1000); 20 mins, single time	Hypotonic (100); 20 mins, single time

Osmolality with unit of mOsmol/kg.