Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy
Inhibition of diabetes-caused upregulation of ICAM-1 by VEGFR1 blockade. ((a)–(c)) Immunofluorescence (IF) results from the nondiabetic mice (a) and the STZ-induced diabetic mice that were treated with rat IgG (b) and MF1 (c). (d) Quantification of IF images showed the statistically significant difference. The results were averaged from 4 mice .