Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy
Prevention of diabetes-caused abnormal localization and degeneration of VE cadherin by VEGFR1 blockade. ((a)–(c)) The representative immunofluorescence (IF) images were taken from the nondiabetic C57BL6 mice (a) and the STZ-induced diabetic mice that were treated with rat IgG (b) or MF1 (c). The diabetic duration was 3 months (or 13 weeks) and the total time of rat IgG or MF1 treatment was 39. Note the pattern difference: the “foggy and cloudy” pattern for rat IgG treatment group and the “clear and vessel-like” pattern for the nondiabetic and MF1 treatment groups. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer plexiform layer. Scale bar: 100 μm. (d) Quantification showed the intensity difference in the three groups. The results were expressed as the mean ± SD .