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Journal of Ophthalmology
Volume 2015 (2015), Article ID 671905, 13 pages
Review Article

Current Trends about Inner Limiting Membrane Peeling in Surgery for Epiretinal Membranes

1Department of Medical and Surgical Specialties, Radiological Specialties and Public Health, Ophthalmology Clinic, University of Brescia, 25123 Brescia, Italy
2Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy
3I.R.C.C.S. Neuromed, Località Camerelle, Pozzilli, 86077 Isernia, Italy

Received 9 February 2015; Accepted 10 May 2015

Academic Editor: John Byron Christoforidis

Copyright © 2015 Francesco Semeraro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The inner limiting membrane (ILM) is the basement membrane of the Müller cells and can act as a scaffold for cellular proliferation in the pathophysiology of disorders affecting the vitreomacular interface. The atraumatic removal of the macular ILM has been proposed for treating various forms of tractional maculopathy in particular for macular pucker. In the last decade, the removal of ILM has become a routine practice in the surgery of the epiretinal membranes (ERMs), with good anatomical results. However many recent studies showed that ILM peeling is a procedure that can cause immediate traumatic effects and progressive modification on the underlying inner retinal layers. Moreover, it is unclear whether ILM peeling is helpful to improve vision after surgery for ERM. In this review, we describe the current understanding about ILM peeling and highlight the beneficial and adverse effects associated with this surgical procedure.