The Correlation between Aquaporin-4 Antibody and the Visual Function of Patients with Demyelinating Optic Neuritis at Onset

Table 3

Frequency of AQP4-Ab in ON among different countries.

	Ethnicity	Age	M : F	AQP4-Ab seropositive
				Total (%)	RON (%)	ION (%)
Our study	China, South	37.3	7 : 29	19/36 (52.8)	8/13 (69.2)	10/23 (43.5)
Long et al. [10]	China, South	31.25	4 : 9	4/13 (30.8)	3/8 (38)	1/5 (20)
Chan et al. [11]	China, South	—	—	3/23 (13)	2/9 (33)	1/14 (14)
Lai et al. [12]	China, North	31.1	12 : 22	11/34 (32.4)	5/11 (45.5)	6/23 (26.1)
Li et al. [13]	China, North	38.89	55 : 135	13/190 (6.8)	10/79 (12.7)	3/114 (2.6)
Takagi et al. [14]	Japan	46	13 : 19	3/32 (9.3)	—	—
Matiello et al. [15]	American	—	2 : 23	—	5/25 (20)	—
Banwell et al. [5]	^#Multi	12.6 (7.4–17.9)	1 : 1.2	1/13 (7.7)	1/5 (20)	0/8 (0)
Petzold et al. [6]	UK	29	3 : 6	4/77 (5.2)	2/36 (6)	2/41 (5)
Costa et al. [7]	Spain	28 (13–48)	34 : 67	3/101 (3.1)	—	—
Jarius et al. [8]	^##Multicountries	34	35 : 104	8/139 (5.8)	5/50 (10)	3/89 (3.4)

ION: isolated monophasic optic neuritis, RON: recurrent optic neuritis; severe ON visual acuity of 20/200 or worse in at least 1 eye at the nadir; pediatric cases; ^#serum from multiple ethnicity of White, Asian, Black, Hispanic, Mestizo, Middle Eastern, and Native Argentinean; ^##serum from Austria, Denmark, France, Germany, Italy, and Turkey.