Table 3: Frequency of AQP4-Ab in ON among different countries.

EthnicityAgeM : FAQP4-Ab seropositive
Total (%)RON (%)ION (%)

Our studyChina, South37.37 : 2919/36 (52.8)8/13 (69.2)10/23 (43.5)
Long et al. [10]China, South31.254 : 94/13 (30.8)3/8 (38)1/5 (20)
Chan et al. [11]China, South3/23 (13)2/9 (33)1/14 (14)
Lai et al. [12]China, North31.112 : 2211/34 (32.4)5/11 (45.5)6/23 (26.1)
Li et al. [13]China, North38.8955 : 13513/190 (6.8)10/79 (12.7)3/114 (2.6)
Takagi et al. [14]Japan4613 : 193/32 (9.3)
Matiello et al. [15]American2 : 235/25 (20)
Banwell et al. [5]#Multi12.6 (7.4–17.9)1 : 1.21/13 (7.7)1/5 (20)0/8 (0)
Petzold et al. [6]UK293 : 64/77 (5.2)2/36 (6)2/41 (5)
Costa et al. [7]Spain28 (13–48)34 : 673/101 (3.1)
Jarius et al. [8]##Multicountries3435 : 1048/139 (5.8)5/50 (10)3/89 (3.4)

ION: isolated monophasic optic neuritis, RON: recurrent optic neuritis; severe ON visual acuity of 20/200 or worse in at least 1 eye at the nadir; pediatric cases; #serum from multiple ethnicity of White, Asian, Black, Hispanic, Mestizo, Middle Eastern, and Native Argentinean; ##serum from Austria, Denmark, France, Germany, Italy, and Turkey.