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Journal of Ophthalmology
Volume 2015, Article ID 693468, 10 pages
http://dx.doi.org/10.1155/2015/693468
Research Article

Novel GUCY2D Gene Mutations in Japanese Male Twins with Leber Congenital Amaurosis

1Department of Ophthalmology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu-shi, Higashi-ku, Shizuoka 431-3192, Japan
2Department of Photomedical Genomics, Basic Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu-shi, Higashi-ku, Shizuoka 431-3192, Japan

Received 3 March 2015; Accepted 28 April 2015

Academic Editor: Terri L. Young

Copyright © 2015 Katsuhiro Hosono et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table 1. List of the 74 genes captured in the present study.

A custom target enrichment library was designed to capture these 74 genes in this list known to be associated with RP or LCA, as reported in the RetNet at the time of system design (https://sph.uth.edu/retnet/; accessed 23th January 2014 ).

Supplementary Table 2. List of all probes used to enrich for the target genes.

Using the Agilent SureDesign online tool (https://earray.chem.agilent.com/suredesign/index.htm), probes were generated for 1182 regions in this list to cover all exons and flanking intronic sequences (intronic sequence ± 25 bp from exon boundaries) of the 74 genes.

  1. Supplementary Tables