Research Article

Evaluation of Four Genetic Variants in Han Chinese Subjects with High Myopia

Table 3

The SNP of rs9307551 in the LOC100506035 gene was associated with HM in this study.

GroupGenotype (%)_HWEModelCrude OR (95% CI)Adjusted OR (95% CI)Adjusted
AAA/CCC

Control200 (20.3)479 (48.5)308 (31.2)0.58011
Patient206 (25.7)408 (50.7)190 (23.6)0.302Allelic1.24 (1.10–1.41)1.33 (1.14–1.54)2.46 × 10−4
Additive 11.40 (1.13–1.73)1.49 (1.15–1.94)0.012
Additive 21.54 (1.20–1.98)1.75 (1.28–2.38)3.37 × 10−4
Dominant1.44 (1.18–1.76)1.59 (1.24–2.01)2.12 × 10−4
Recessive1.24 (1.00–1.52)1.34 (1.04–1.73)0.025

Crude ORs (95% CI) were determined by the test, patients versus controls. Adjusted ORs (95% CI) and adjusted values were obtained by adjusting for age and sex.
Genotype (AA/AC/CC) analyses were conducted for the allelic model (A compared with C), additive model 1 (AC compared with CC), additive model 2 (AA compared with CC), dominant model (AA + AC compared with CC), and the recessive model (AA compared with AC + CC).