Research Article
Evaluation of Four Genetic Variants in Han Chinese Subjects with High Myopia
Table 4
The association between HM and rs9307551 was gender-specific.
| Gender | Group | Genotype (%) | _HWE | Model | Crude OR (95% CI) | Adjusted OR# (95% CI) | Adjusted | AA | A/C | CC |
| Female | Control | 82 (20.3) | 191 (47.3) | 131 (32.4) | 0.417 | | 1 | 1 | | Patient | 133 (26.9) | 259 (52.4) | 102 (20.7) | 0.241 | Allelic | 1.45 (1.20–1.74) | 1.47 (1.19–1.84) | 2.86 × 10−4 | | | | | | Additive 1 | 1.74 (1.27–2.40) | 1.66 (1.28–2.45) | 0.012 | | | | | | Additive 2 | 2.08 (1.43–3.04) | 2.12 (1.39–3.24) | 4.65 × 10−4 | | | | | | Dominant | 1.84 (1.36–2.49) | 1.95 (1.40–2.72) | 7.99 × 10−5 | | | | | | Recessive | 1.45 (1.06–1.98) | 1.41 (1.00–2.01) | 0.050 |
| Male | Control | 118 (20.2) | 288 (49.4) | 177 (30.4) | 0.966 | | 1 | 1 | | Patient | 73 (23.5) | 149 (48.1) | 88 (28.4) | 0.521 | Allelic | 1.11 (0.91–1.35) | 1.18 (0.79–1.75) | 0.411 | | | | | | Additive 1 | 1.24 (0.84–1.83) | 1.18 (0.94–1.47) | 0.142 | | | | | | Additive 2 | 1.04 (0.76–1.44) | 1.39 (0.89–2.17) | 0.142 | | | | | | Dominant | 1.09 (0.81–1.49) | 1.24 (0.88–1.75) | 0.223 | | | | | | Recessive | 1.21 (0.87–1.69) | 1.25 (0.86–1.82) | 0.237 |
|
|
value and ORs (95% CI) were adjusted by age.
|