Table 5: In silico analysis for novel missense mutations.

GeneProtein variantDNA variantPrediction
for damage

CRX p.R40Wc.118C>T4 of 4
EYS p.K4Ec.10A>G2 of 4
EYS p.R26Qc.77G>A2 of 4
EYS p.M12Tc.35T>C2 of 4
EYS p.E47Dc.141A>T3 of 4
EYS p.Q76Hc.228G>C2 of 4
EYS p.C211Yc.632G>A4 of 4
EYS p.I256Mc.768A>G2 of 4
EYS p.G484Rc.1450G>A3 of 4
EYS p.N1205Tc.3614A>C2 of 4
EYS p.K1633Ec.4897A>G2 of 4
EYS p.L1655Mc.4963 T>A2 of 4
EYS p.L1802Fc.5404C>T2 of 4
EYS p.G2186Ec.6557G>A2 of 4
EYS p.I2188Tc.6563T>C1 of 4
EYS p.R2604Cc.7810C>T2 of 4
EYS p.T2683Ic.8048C>T0 of 4
EYS p.D2767Hc.8299G>C3 of 4
EYS p.L2784Rc.8351T>G2 of 4
EYS p.I3091Tc.9272T>C2 of 4
PROM1 p.N580Hc.1738A>C3 of 4
RDS p.K15Rc.44A>G1 of 3
RDS p.A116Sc.346G>T0 of 4
RDS p.K154Qc.460A>C0 of 4
RHO p.G101Ec.302G>A4 of 4

Bold indicates in silico analysis indicates pathogenic higher than 50% rates.