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Journal of Ophthalmology
Volume 2015, Article ID 865083, 7 pages
Review Article

Effects of Vitreomacular Adhesion on Age-Related Macular Degeneration

Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea

Received 23 February 2015; Accepted 7 June 2015

Academic Editor: John Byron Christoforidis

Copyright © 2015 Eui Chun Kang and Hyoung Jun Koh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Herein, we review the association between vitreomacular adhesion (VMA) and neovascular age-related macular degeneration (AMD). Meta-analyses have shown that eyes with neovascular AMD are twice as likely to have VMA as normal eyes. VMA in neovascular AMD may induce inflammation, macular traction, decrease in oxygenation, sequestering of vascular endothelial growth factor (VEGF), and other cytokines or may directly stimulate VEGF production. VMA may also interfere with the treatment effects of anti-VEGF therapy, which is the standard treatment for neovascular AMD, and releasing VMA can improve the treatment response to anti-VEGF treatment in neovascular AMD. We also reviewed currently available methods of relieving VMA.