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Journal of Ophthalmology
Volume 2016, Article ID 1051572, 5 pages
Research Article

Mean Platelet Volume in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy

1School of Medicine, Department of Ophthalmology, Dicle University, 21280 Diyarbakir, Turkey
2School of Medicine, Department of Immunology, Dicle University, 21280 Diyarbakir, Turkey

Received 15 August 2015; Revised 25 November 2015; Accepted 11 January 2016

Academic Editor: Ciro Costagliola

Copyright © 2016 Muhammed Şahin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. We aimed to investigate the mean platelet volume (MPV) of the patients with nonarteritic anterior ischemic optic neuropathy (NAION). Methods. The medical records of 46 patients with the diagnosis of NAION and 90 control subjects were retrospectively evaluated. All participants underwent complete ocular examination including intraocular pressure (IOP) measurement. Hematocrit, MPV, hemoglobin, and platelet levels of the patients with NAION were compared with those of control subjects. Results. There was no significant difference between the groups in platelet counts (). NAION group had significantly higher MPV values ( fL) than that of control subjects ( fL) (). Multivariate logistic regression analysis showed that MPV is an independent predictor of NAION (odds ratio = 1.61; 95% confidence interval (CI) = 1.13–2.28; ). The mean IOP was significantly higher in NAION group (). IOP was also found as an independent predictor of NAION according to the regression analysis (OR = 1.27; 95% CI = 1.08–1.48; ). Conclusion. Our results demonstrated that the MPV values were significantly higher in NAION patients, suggesting that larger platelets may contribute to the pathogenesis of the NAION.