Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis

Table 2

Principle characteristics of the studies included in the meta-analysis for association between eNOS rs1799983 and POAG.

First author	Cohorts	Year	Ethnicity	Genotyping	Case					Control					Control
					Size	TT	TC	CC	MAF	Size	TT	TC	CC	MAF	HWE ()
Lin [15]	All	2005	Asians	Taqman	66	55	11	0	0.08	100	84	16	0	0.08	0.38
Fan [16]	All	2010	Asians	NA	397	310	77	10	0.12	201	157	40	4	0.12	0.45
Kang [17]	All	2011	Caucasians	Taqman	518	202	232	84	0.39	1501	580	673	248	0.39	0.03
	Male	2011	Caucasians	Taqman	153	65	66	22	0.36	457	166	215	76	0.40	0.65
	Female	2011	Caucasians	Taqman	365	137	166	62	0.40	1044	414	458	172	0.38	0.02
Magalhães da Silva [18]	All	2012	Caucasians	Taqman	89	42	39	8	0.31	123	74	38	11	0.24	0.07
	Male	2012	Caucasians	Taqman	28	16	10	2	0.25	61	35	22	4	0.25	0.83
	Female	2012	Caucasians	Taqman	61	26	28	7	0.34	62	39	20	3	0.21	0.83
Emam [19]	All	2014	Caucasians	PCR-RFLP	160	63	59	38	0.42	110	60	38	12	0.28	0.12
	Male	2014	Caucasians	PCR-RFLP	76	32	26	18	0.08	56	30	19	7	0.08	0.17
	Female	2014	Caucasians	PCR-RFLP	84	31	33	20	0.12	54	30	19	5	0.12	0.44

NA: data not available; MAF: Minor Allele Frequency; HWE: Hardy-Weinberg equilibrium; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism.