Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis

Table 3

Summary risk estimates for association between eNOS rs2070744 and POAG.

	Comparisons	Studies ()	Model	Pooled estimate		Heterogeneity; (%)		Egger’s; test ()	Begg’s; test ()
				OR (95% CI)
Overall	T versus C	4	F	0.736 (0.594–0.912)	0.005	44.8	0.143	0.724	0.734
	TT versus CC	4	F	0.498 (0.296–0.838)	0.009	21.6	0.279	0.236	1.000
	TC versus CC	4	F	0.725 (0.425–1.239)	0.240	25.0	0.264	0.561	1.000
	TT + TC versus CC	4	F	0.573 (0.348–0.943)	0.029	25.1	0.263	0.379	1.000
	TT versus TC + CC	4	F	0.746 (0.575–0.967)	0.027	34.6	0.205	0.873	1.000
Female	T versus C	2	F	0.490 (0.333–0.721)	0.000	0.0	0.887
	TT versus CC	2	F	0.268 (0.112–0.642)	0.003	0.0	0.913
	TC versus CC	2	F	0.489 (0.200–1.196)	0.117	0.0	0.732
	TT + TC versus CC	2	F	0.328 (0.144–0.749)	0.008	0.0	0.764
	TT versus TC + CC	2	F	0.423 (0.260–0.689)	0.001	0.0	0.896
Male	T versus C	2	F	0.711 (0.467–1.081)	0.111	8.4	0.296
	TT versus CC	2	F	0.496 (0.211–1.175)	0.111	0.0	0.452
	TC versus CC	2	F	0.604 (0.244–1.496)	0.276	0.0	0.623
	TT + TC versus CC	2	F	0.513 (0.230–1.144)	0.103	0.0	0.476
	TT versus TC + CC	2	F	0.688 (0.406–1.165)	0.164	0.0	0.328
Asians	T versus C	2	F	0.971 (0.695–1.358)	0.864	0.0	0.967
	TT versus CC	2	F	0.790 (0.244–2.558)	0.694	—	—
	TC versus CC	2	F	0.770 (0.227–2.610)	0.675	—	—
	TT + TC versus CC	2	F	0.786 (0.243–2.537)	0.687	—	—
	TT versus TC + CC	2	F	0.990 (0.684–1.431)	0.955	0.0	0.921
Caucasians	T versus C	2	F	0.607 (0.460–0.803)	0.001	3.2	0.310
	TT versus CC	2	F	0.444 (0.249–0.791)	0.006	46.1	0.173
	TC versus CC	2	R	0.715 (0.394–1.296)	0.269	62.4	0.103
	TT + TC versus CC	2	R	0.534 (0.308–0.925)	0.025	57.7	0.124
	TT versus TC + CC	2	F	0.563 (0.390–0.812)	0.002	0.0	0.813

OR: odds ratio; CI: confidence interval; : value for test; : value for -test; F: fixed-effects mode; R: random-effects model; —: data not available.