Accelerated Corneal Collagen Cross-Linking Using Topography-Guided UV-A Energy Emission: Preliminary Clinical and Morphological Outcomes

Figure 6

IVCM scans in the first month after high-irradiance topography-guided CXL. Different demarcation lines were documented at 150 µm depth in the flattest areas (48 D and under) irradiated at 7.2 J/cm² ((a), (b), and (c)); at 250 µm depth in the area (>48 D and ≤52 D) irradiated at 10 J/cm² E dose (d); at 300 µm depth in the steepest cone area (>52 D) irradiated at 15 J/cm² E dose (e). IVCM also showed hyperreflectivity of corneal tissue and keratocytes apoptosis associated with dense trabecular patterned lacunar edema and nerve disappearance ((a), (b), and (c)). No endothelial damage was documented (f).

(a)

(b)

(c)

(d)

(e)

(f)