Journal of Ophthalmology

Journal of Ophthalmology / 2016 / Article

Comment on “Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer’s Type Dementia”

  • Abdullah Ilhan | Umit Yolcu | Fahrettin Akay |
  •  Article ID 8737082 |
  •  Published 28 Jun 2016
  • | View Article

Comment on “Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer’s Type Dementia”

  • Salih Uzun |
  •  Article ID 5392105 |
  •  Published 06 Sep 2016
  • | View Article

Response to: Comment on “Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer’s Type Dementia”

  • Mehmet Bulut | Aylin Yaman | ... | Ebru Kaya Başar |
  •  Article ID 5496356 |
  •  Published 17 Oct 2016
  • | View Article

Response to: Comment on “Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer’s Type Dementia”

  • Mehmet Bulut | Aylin Yaman | ... | Ebru Kaya |
  •  Article ID 2898704 |
  •  Published 29 Nov 2016

Letter to the Editor | Open Access

Volume 2016 |Article ID 2898704 | 1 page | https://doi.org/10.1155/2016/2898704

Response to: Comment on “Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer’s Type Dementia”

Academic Editor: Jesús Pintor
Received27 Jun 2016
Accepted25 Aug 2016
Published29 Nov 2016

We would like to thank Ilhan et al. [1] for their comments regarding our article. In our study, we found out that choroidal thickness (CT) decreased in the eyes of patients with both Alzheimer’s type dementia (ATD) and mild cognitive impairment (MCI) compared to the healthy control group. Therefore, we suggested that CT value could be used as a new biomarker in early diagnosis of ATD and MCI patients and follow-up of their progression [2].

We performed statistical analysis using the values of single eyes and both eyes in our study. We found statistically significant results for both single eyes and both eyes, which was consistent with the suggestion of Ilhan et al. [1]. For that reason, we preferred using the values of both eyes in order to extend the number of data in our paper. We also found out in our study that both parapapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GC-IPL) thickness decreased in MCI and ATD patients compared to the healthy control group. However, we did not use these data in our paper because we wanted to use them in another study for an extended group of participants. We think that the pathology of central nervous system in ATD and MCI patients may affect both RNFL and GC-IPL in eyes at an early stage. There are publications in the literature relating to this matter [3, 4].

In our study, we found a positively significant correlation between the mini mental state examination (MMSE) test score and CT values, whereas these findings were obtained before the participants were assigned to the groups and we used these data in our paper. We also analyzed the correlation in each group. However, we could not find any statistically significant correlation. This might be associated with the low number of data in each group.

Competing Interests

None of the authors has a financial and proprietary interest in any material or method mentioned and there is no public or private support.

References

  1. A. Ilhan, U. Yolcu, and F. Akay, “Comment on ‘Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer’s Type Dementia’,” Journal of Ophthalmology, vol. 2016, Article ID 8737082, 1 page, 2016. View at: Publisher Site | Google Scholar
  2. M. Bulut, A. Yaman, M. K. Erol et al., “Choroidal thickness in patients with mild cognitive impairment and Alzheimer’s type dementia,” Journal of Ophthalmology, vol. 2016, Article ID 7291257, 7 pages, 2016. View at: Publisher Site | Google Scholar
  3. E. O. Oktem, E. Derle, S. Kibaroglu, C. Oktem, I. Akkoyun, and U. Can, “The relationship between the degree of cognitive impairment and retinal nerve fiber layer thickness,” Neurological Sciences, vol. 36, no. 7, pp. 1141–1146, 2015. View at: Publisher Site | Google Scholar
  4. C. Y.-L. Cheung, Y. T. Ong, S. Hilal et al., “Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease,” Journal of Alzheimer's Disease, vol. 45, no. 1, pp. 45–56, 2015. View at: Publisher Site | Google Scholar

Copyright © 2016 Mehmet Bulut et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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