Zeaxanthin: Review of Toxicological Data and Acceptable Daily Intake

Table 4

Plasma and liver concentration of zeaxanthin in adults and weanlings in the two-generation study in rats [31].

⁢Zeaxanthin concentration (/L or /kg) at nominal dosage (mg/kg bw/day)
Dosage	0	0	50	150	500
P generation
Plasma, /L
Adults
Male	—	—	24	47	111
Female	—	—	19	29	71
Weanlings	—	—	61	127	353
Liver, μ/kg
Adults
Male	14	—	599	1121	2581
Female	4	5	1147	1992	3159
Weanlings	—	—	4015	10892	23836
F1 generation
Plasma, μ/L
Adults
Male	—	—	22	42	109
Female	—	—	20	42	87
Weanlings	—	—	52	85	213
Liver, μ/kg
Adults
Male	—	—	114	645	1689
Female	11	—	1077	1382	3785
Weanlings	—	11	4313	7904	21611