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Journal of Ophthalmology
Volume 2016, Article ID 3762674, 6 pages
Research Article

Comparison of Subconjunctival Mitomycin C and 5-Fluorouracil Injection for Needle Revision of Early Failed Trabeculectomy Blebs

The Second People’s Hospital of Jinan, No. 148 Jingyi Road, Jinan 250001, China

Received 19 October 2015; Accepted 22 December 2015

Academic Editor: Vital P. Costa

Copyright © 2016 Wei Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. To compare the efficacy of needle revision with 5-fluorouracil (5-FU) and mitomycin C (MMC) on dysfunctional filtration blebs shortly after trabeculectomy. Methods. It is a prospective randomized study comparing needle revision augmented with MMC or 5-FU for failed trabeculectomy blebs. Results. To date 71 patients (75 eyes) have been enrolled, 40 eyes in the MMC group and 35 in the 5-FU group. 68 patients (72 eyes) have completed 12-month follow-up, 38 eyes in the MMC group and 34 in the 5-FU group. The mean IOP before and that after needle revision in the MMC group were  mmHg and .4 mmHg, respectively (), and in the 5-FU group were  mmHg and  mmHg, respectively (). At 12-month follow-up, complete success rates were 57.5% for MMC group and 34.3% for 5-FU group (; log-rank test) and 75% and 60% (; log-rank test), respectively, for the qualified success. Complication rates between the two groups were not statistically different (). Conclusions. Needle revision and subconjunctival MMC injection were more effective than needling and subconjunctival 5-FU injection for early dysfunctional filtration blebs after trabeculectomies.