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Journal of Ophthalmology
Volume 2016, Article ID 4108490, 7 pages
Clinical Study

Intravitreal Ranibizumab Injection as an Adjuvant in the Treatment of Neovascular Glaucoma Accompanied by Vitreous Hemorrhage after Diabetic Vitrectomy

1Department of Ophthalmology, Ruijin Hospital, School of Medicine, The Jiaotong University, Shanghai 200025, China
2Department of Ophthalmology, Ruijin Hospital, Luwan Branch, School of Medicine, The Jiaotong University, Shanghai 200025, China
3Department of Ophthalmology, The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 310000, China

Received 25 December 2015; Revised 26 March 2016; Accepted 27 April 2016

Academic Editor: Paolo Lanzetta

Copyright © 2016 Xi Shen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To determine the efficacy of intravitreal ranibizumab injection as adjuvant therapy in the treatment of neovascular glaucoma (NVG) accompanied by postvitrectomy diabetic vitreous hemorrhage (PDVH). Methods. Eighteen NVG patients (18 eyes) accompanied by PDVH were enrolled in this prospective, monocenter, 12-month, interventional case series. The consecutive 18 patients with an IOP ≥ 25 mmHg despite being treated with the maximum medical therapy were treated with intravitreal ranibizumab injections. Vitreous surgery or/with Ahmed valve implantation were indicated if no clinical improvement in vitreous haemorrhage and uncontrolled IOP was shown. Results. Ten patients got clear vitreous and controlled IOP only with injections of ranibizumab without additional surgery. Vitrectomy or/with Ahmed valve implantation was administered in the other 8 eyes due to uncontrolled VH and IOP. At follow-up month 12, all the 18 eyes gained clear vitreous. At month 12 BCVA improved significantly compared to baseline. The baseline and follow-up at month 12 IOP/medication usage were  mmHg on medications and  mmHg on medications, respectively. Conclusions. The findings suggest that intravitreal ranibizumab injection as adjuvant therapy for treatment of NVG accompanied by PDVH may be safe and potentially effective. This clinical trial is registered with NCT02647515.