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Journal of Ophthalmology
Volume 2016 (2016), Article ID 6016491, 6 pages
http://dx.doi.org/10.1155/2016/6016491
Research Article

Efficacy and Safety in Retinal Vein Occlusion Treated with at Least Three Consecutive Intravitreal Dexamethasone Implants

1Department of Ophthalmology, Claude Huriez Hospital, Michel Polonovski Street, 59037 Lille Cedex, France
2Department of Ophthalmology, Orleans La Source Hospital, 14 rue de l’Hôpital, 45100 Orleans, France
3Department of Biostatistics, EA2694, CHRU Lille, University of Lille, 59000 Lille, France
4Department of Ophthalmology, Saint-Vincent de Paul Hospital, Lille Catholic University, Boulevard de Belfort, BP 387, 59020 Lille Cedex, France

Received 29 October 2015; Revised 20 January 2016; Accepted 21 January 2016

Academic Editor: Stephen Charn Beng Teoh

Copyright © 2016 Julia Proença Pina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To evaluate the effects of repeated intravitreal dexamethasone implant (DI) (Ozurdex®) in eyes with macular edema (ME) due to retinal vein occlusion (RVO). Methods. Multicenter observational study including patients who received more than three consecutive DI on an “as-needed” basis for the treatment of ME in RVO. Results. A total of 18 eyes were included for analysis. Mean interval of retreatment with DI was 5.1 months between the first and second DI and 5.4 months following the second DI. Baseline BCVA was 0.74 ± 0.08 log-Mar; it significantly improved to 0.45 ± 0.04 2 months after the 3rd DI. There was no significant difference between the 3 first postinjection BCVA. CMT decreased from 617 μm ± 120 μm (baseline) to 330 ± 109 μm two months after the third DI. Elevated intraocular pressure occurred in 50% and was controlled medically. Cataract progression leading to cataract surgery occurred in 69% of phakic eyes after a mean interval of 17 months. Conclusion. Repeated DI on an “as-needed” basis, with a retreatment interval <6 months, are effective in the long term in the management of ME due to RVO. Rates of increased intraocular pressure and cataract surgery seem to be higher than previously described when eyes were followed during a longer period.