SENP1-Mediated Desumoylation of DBC1 Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes

Figure 5

SENP1 inhibited the DBC1 sumoylation induced by high glucose. (a) BRPCs incubated with normal (NG) or high glucose (HG) for 48 h were subjected to immunoprecipitation with IgG or anti-DBC1 antibody followed by immunoblot analysis. (b) SENP1 was overexpressed in BRPCs under high glucose for 48 h. Their lysates were subjected to immunoprecipitation with IgG or anti-DBC1 antibody followed by immunoblot analysis.

(a)

(b)