TY - JOUR A2 - Kurihara, Toshihide AU - Novais, Eduardo A. AU - BadarĂ³, Emmerson AU - Hirai, Flavio E. AU - Jorge, Felipe Abdo AU - Leal, Paula AU - Farah, Michel Eid AU - Rodrigues, Eduardo B. PY - 2016 DA - 2016/05/05 TI - Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case Series SP - 6971831 VL - 2016 AB - Purpose. To evaluate daily spectral-domain optical coherence tomography (SD-OCT) changes in naive-treatment patients with diagnosis of exudative age-related macular degeneration (AMD) treated with intravitreous bevacizumab (1.25 mg), during a 30-day follow-up period. Methods. In prospective, interventional study, SD-OCT was performed daily for 30 days after the first intravitreal injection. The baseline, initial-decrease, minimal, and final central retinal thicknesses (CRTs) were assessed. Results. Nine eyes of nine patients with neovascular AMD were enrolled. The mean baseline CRT was 625.3±182.5μm, and the mean final CRT was 383.4±163.0μm (mean difference, 206.1±167.6μm), a difference that reached significance (P=0.006). After the first injection, the initial decrease in the CRT was seen as an average of one day after injection (mean CRT, 503.6±189.10μm; P=0.0431). The speed of the reduction in the CRT tended to decrease by day 17. The mean CRT was 336.5±105.44μm and the mean minimal CRT on day 30 was 320.75±96.38μm. Conclusion. The CRT decreased early after the first injection. We observed a tendency for reductions in the speed with which the CRT decreased by day 17 after the first injection, which may affect retreatment regime. SN - 2090-004X UR - https://doi.org/10.1155/2016/6971831 DO - 10.1155/2016/6971831 JF - Journal of Ophthalmology PB - Hindawi Publishing Corporation KW - ER -