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Journal of Ophthalmology
Volume 2016, Article ID 6971831, 6 pages
Clinical Study

Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case Series

Department of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, Brazil

Received 14 January 2016; Revised 18 March 2016; Accepted 10 April 2016

Academic Editor: Toshihide Kurihara

Copyright © 2016 Eduardo A. Novais et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To evaluate daily spectral-domain optical coherence tomography (SD-OCT) changes in naive-treatment patients with diagnosis of exudative age-related macular degeneration (AMD) treated with intravitreous bevacizumab (1.25 mg), during a 30-day follow-up period. Methods. In prospective, interventional study, SD-OCT was performed daily for 30 days after the first intravitreal injection. The baseline, initial-decrease, minimal, and final central retinal thicknesses (CRTs) were assessed. Results. Nine eyes of nine patients with neovascular AMD were enrolled. The mean baseline CRT was μm, and the mean final CRT was μm (mean difference, μm), a difference that reached significance (). After the first injection, the initial decrease in the CRT was seen as an average of one day after injection (mean CRT, μm; ). The speed of the reduction in the CRT tended to decrease by day 17. The mean CRT was μm and the mean minimal CRT on day 30 was μm. Conclusion. The CRT decreased early after the first injection. We observed a tendency for reductions in the speed with which the CRT decreased by day 17 after the first injection, which may affect retreatment regime.