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Journal of Ophthalmology
Volume 2016 (2016), Article ID 8643174, 8 pages
http://dx.doi.org/10.1155/2016/8643174
Research Article

Effect of Hydroxychloroquine on the Retinal Layers: A Quantitative Evaluation with Spectral-Domain Optical Coherence Tomography

1Department of Ophthalmology, Fatih University Medical Faculty Hospital, 34844 Istanbul, Turkey
2Department of Rheumatology, Fatih University Medical Faculty Hospital, 34844 Istanbul, Turkey

Received 7 March 2016; Revised 13 July 2016; Accepted 19 July 2016

Academic Editor: Suphi Taneri

Copyright © 2016 Hasim Uslu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. F. Marmor, “Comparison of screening procedures in hydroxychloroquine toxicity,” Archives of Ophthalmology, vol. 130, no. 4, pp. 461–469, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. M. F. Marmor, U. Kellner, T. Y. Lai et al., “Recommendations on screening for chloroquine and hydroxychloroquine retinopathy (2016 Revision),” Ophthalmology, vol. 123, no. 6, pp. 1386–1394, 2016. View at Publisher · View at Google Scholar
  3. D. J. Browning, Hydroxychloroquine and Chloroquine Retinopathy, Springer, New York, NY, USA, 1st edition, 2014.
  4. W. Frederick and M. F. Marmor, “Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus,” Arthritis Care & Research, vol. 62, no. 6, pp. 775–784, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. H. N. Bernstein, “Ocular safety of hydroxychloroquine,” Annals of Ophthalmology, vol. 23, no. 8, pp. 292–296, 1991. View at Google Scholar · View at Scopus
  6. J. A. Rodriguez-Padilla, T. R. Hedges III, B. Monson et al., “High-speed ultra-high-resolution optical coherence tomography findings in hydroxychloroquine retinopathy,” Archives of Ophthalmology, vol. 125, no. 6, pp. 775–780, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. D. J. Browning, “Impact of the revised american academy of ophthalmology guidelines regarding hydroxychloroquine screening on actual practice,” American Journal of Ophthalmology, vol. 155, no. 3, pp. 418–428, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Arai, I. Kimura, Y. Imamura et al., “Photoreceptor inner and outer segment layer thickness in multiple evanescent white dot syndrome,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 252, no. 10, pp. 1645–1651, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. M. F. Marmor, R. E. Carr, M. Easterbrook, A. A. Farjo, and W. F. Mieler, “Recommendations on screening for chloroquine and hydroxychloroquine retinopathy: a report by the American Academy of Ophthalmology,” Ophthalmology, vol. 109, no. 7, pp. 1377–1382, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. M. F. Marmor and J. Hu, “Effect of disease stage on progression of hydroxychloroquine retinopathy,” JAMA Ophthalmology, vol. 132, no. 9, pp. 1105–1112, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Pasadhika and G. A. Fishman, “Effects of chronic exposure to hydroxychloroquine or chloroquine on inner retinal structures,” Eye, vol. 24, no. 2, pp. 340–346, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Michaelides, N. B. Stover, P. J. Francis, and R. G. Weleber, “Retinal toxicity associated with hydroxychloroquine and chloroquine: risk factors, screening, and progression despite cessation of therapy,” Archives of Ophthalmology, vol. 129, no. 1, pp. 30–39, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. M. F. Marmor, U. Kellner, T. Y. Y. Lai, J. S. Lyons, W. F. Mieler, and American Academy of Ophthalmology, “Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy,” Ophthalmology, vol. 118, no. 2, pp. 415–422, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. D. J. Browning, C. Lee, and D. Rotberg, “The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women,” Clinical Ophthalmology, vol. 8, pp. 1401–1407, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Anderson, G. R. Blaha, and J. L. Marx, “Humphrey visual field findings in hydroxychloroquine toxicity,” Eye, vol. 25, no. 12, pp. 1535–1545, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. K. V. Bhavsar, L. K. Mukkamala, and K. B. Freund, “Multimodal imaging in a severe case of hydroxychloroquine toxicity,” Ophthalmic Surgery Lasers and Imaging Retina, vol. 46, no. 3, pp. 377–379, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Korah and T. Kuriakose, “Optical coherence tomography in a patient with chloroquine-induced maculopathy,” Indian Journal of Ophthalmology, vol. 56, no. 6, pp. 511–513, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. A. R. Rosenthal, H. Kolb, D. Bergsma, D. Huxsoll, and J. L. Hopkins, “Chloroquine retinopathy in the rhesus monkey,” Investigative Ophthalmology and Visual Science, vol. 17, no. 12, pp. 1158–1175, 1978. View at Google Scholar · View at Scopus
  19. M. S. Ramsey and B. S. Fine, “Chloroquine toxicity in the human eye histopathologic observations by electron microscopy,” American Journal of Ophthalmology, vol. 73, no. 2, pp. 229–235, 1972. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Pasadhika, G. A. Fishman, D. Choi, and M. Shahidi, “Selective thinning of the perifoveal inner retina as an early sign of hydroxychloroquine retinal toxicity,” Eye, vol. 24, no. 5, pp. 756–763, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. M. G. Lee, S. J. Kim, D.-I. Ham et al., “Macular retinal ganglion cell–inner plexiform layer thickness in patients on hydroxychloroquine therapy,” Investigative Ophthalmology and Visual Science, vol. 56, no. 1, pp. 396–402, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Chen, D. M. Brown, M. S. Benz et al., “Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy (the ‘flying saucer’ sign),” Clinical Ophthalmology, vol. 4, no. 1, pp. 1151–1158, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. J. C. S. Yam and A. K. H. Kwok, “Ocular toxicity of hydroxychloroquine,” Hong Kong Medical Journal, vol. 12, no. 4, pp. 294–304, 2006. View at Google Scholar · View at Scopus
  24. G. J. Mahon, H. R. Anderson, T. A. Gardiner, S. McFarlane, D. B. Archer, and A. W. Stitt, “Chloroquine causes lysosomal dysfunction in neural retina and RPE: implications for retinopathy,” Current Eye Research, vol. 28, no. 4, pp. 277–284, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Pikkel, O. Chassid, A. Sharabi-Nov, and I. Beiran, “A retrospective evaluation of the effect of hydroxyquinine on RPE thickness,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 251, no. 7, pp. 1687–1690, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Mititelu, B. J. Wong, M. Brenner, P. J. Bryar, L. M. Jampol, and A. A. Fawzi, “Progression of hydroxychloroquine toxic effects after drug therapy cessation: new evidence from multimodal imaging,” JAMA Ophthalmology, vol. 131, no. 9, pp. 1187–1197, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. R. K. Maturi, M. Yu, and R. G. Weleber, “Multifocal electroretinographic evaluation of long-term hydroxychloroquine users,” Archives of Ophthalmology, vol. 122, no. 7, pp. 973–981, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Y. Y. Lai, W.-M. Chan, H. Li, R. Y. K. Lai, and D. S. C. Lam, “Multifocal electroretinographic changes in patients receiving hydroxychloroquine therapy,” American Journal of Ophthalmology, vol. 140, no. 5, pp. 794–807, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Cukras, N. Huynh, S. Vitale, W. T. Wong, F. L. Ferris III, and P. A. Sieving, “Subjective and objective screening tests for hydroxychloroquine toxicity,” Ophthalmology, vol. 122, no. 2, pp. 356–366, 2015. View at Publisher · View at Google Scholar · View at Scopus