TY - JOUR A2 - Yang, Shun-Fa AU - Bi, Ming-Chao AU - Hose, Nicole AU - Xu, Cai-Lian AU - Zhang, Chen AU - Sassoon, Jodi AU - Song, E. PY - 2016 DA - 2016/01/28 TI - Nonlethal Levels of Zeaxanthin Inhibit Cell Migration, Invasion, and Secretion of MMP-2 via NF-κB Pathway in Cultured Human Uveal Melanoma Cells SP - 8734309 VL - 2016 AB - Zeaxanthin at nonlethal dosages (3–10 μM) significantly inhibited the cell migration of cultured uveal melanoma cells (C918 cell line) as determined by wound healing assay and Boyden chamber assay. Matrigel invasion assay showed that cell invasion of uveal melanoma cells could be significantly inhibited by zeaxanthin. Secretion of MMP-2 by melanoma cells was significantly inhibited by zeaxanthin in a dose-dependent manner as measured by ELISA kit. Zeaxanthin also significantly inhibited the NF-κB levels in nuclear extracts of the UM cells, which is the upstream of the MMP-2 secretion. These results suggest that zeaxanthin might be a potentially therapeutic approach in the prevention of metastasis in uveal melanoma. SN - 2090-004X UR - https://doi.org/10.1155/2016/8734309 DO - 10.1155/2016/8734309 JF - Journal of Ophthalmology PB - Hindawi Publishing Corporation KW - ER -