Table of Contents Author Guidelines Submit a Manuscript
Journal of Ophthalmology
Volume 2016 (2016), Article ID 9392640, 7 pages
http://dx.doi.org/10.1155/2016/9392640
Research Article

Scheimpflug Imaging Parameters Associated with Tear Mediators and Bronchial Asthma in Keratoconus

1Department of Ophthalmology, University of Debrecen, Debrecen 4012, Hungary
2Orbident Refractive Surgery and Medical Center, Debrecen 4012, Hungary
3Department of Immunology, University of Debrecen, Debrecen 4012, Hungary

Received 16 October 2015; Accepted 14 December 2015

Academic Editor: Vito Romano

Copyright © 2016 Dorottya Pásztor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. H. Krachmer, R. S. Feder, and M. W. Belin, “Keratoconus and related non-inflammatory corneal thinning disorders,” Survey of Ophthalmology, vol. 28, no. 4, pp. 293–322, 1984. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. S. Rabinowitz, “Keratoconus,” Survey of Ophthalmology, vol. 42, no. 4, pp. 297–319, 1998. View at Publisher · View at Google Scholar · View at Scopus
  3. A. E. Davidson, S. Hayes, A. J. Hardcastle, and S. J. Tuft, “The pathogenesis of keratoconus,” Eye, vol. 28, no. 2, pp. 189–195, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. V. Galvis, T. Sherwin, A. Tello, J. Merayo, R. Barrera, and A. Acera, “Keratoconus: an inflammatory disorder?” Eye, vol. 29, no. 7, pp. 843–859, 2015. View at Publisher · View at Google Scholar
  5. I. Lema and J. A. Durán, “Inflammatory molecules in the tears of patients with keratoconus,” Ophthalmology, vol. 112, no. 4, pp. 654–659, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. I. Lema, T. Sobrino, J. A. Durán, D. Brea, and E. Díez-Feijoo, “Subclinical keratoconus and inflammatory molecules from tears,” British Journal of Ophthalmology, vol. 93, no. 6, pp. 820–824, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Pannebaker, H. L. Chandler, and J. J. Nichols, “Tear proteomics in keratoconus,” Molecular Vision, vol. 16, pp. 1949–1957, 2010. View at Google Scholar · View at Scopus
  8. A. Acera, E. Vecino, I. Rodríguez-Agirretxe et al., “Changes in tear protein profile in keratoconus disease,” Eye, vol. 25, no. 9, pp. 1225–1233, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. S. A. Balasubramanian, S. Mohan, D. C. Pye, and M. D. P. Willcox, “Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus,” Acta Ophthalmologica, vol. 90, no. 4, pp. e303–e309, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. S. A. Balasubramanian, V. C. Wasinger, D. C. Pye, and M. D. Willcox, “Preliminary identification of differentially expressed tear proteins in keratoconus,” Molecular Vision, vol. 19, pp. 2124–2134, 2013. View at Google Scholar
  11. R. Sorkhabi, A. Ghorbanihaghjo, N. Taheri, and M. H. Ahoor, “Tear film inflammatory mediators in patients with keratoconus,” International Ophthalmology, vol. 35, no. 4, pp. 467–472, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. I. Lema, D. Brea, R. Rodríguez-González, E. Díez-Feijoo, and T. Sobrino, “Proteomic analysis of the tear film in patients with keratoconus,” Molecular Vision, vol. 16, pp. 2055–2061, 2010. View at Google Scholar · View at Scopus
  13. A. S. Jun, L. Cope, C. Speck et al., “Subnormal cytokine profile in the tear fluid of keratoconus patients,” PLoS ONE, vol. 6, no. 1, Article ID e16437, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. S. A. Balasubramanian, D. C. Pye, and M. D. P. Willcox, “Levels of lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus,” Experimental Eye Research, vol. 96, no. 1, pp. 132–137, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. M. C. Kenney, M. Chwa, S. R. Atilano et al., “Increased levels of catalase and cathepsin V/l2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder,” Investigative Ophthalmology and Visual Science, vol. 46, no. 3, pp. 823–832, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. D. W. Sabiston, “The association of keratoconus, dermatitis and asthma,” Transactions of the Ophthalmological Society of New Zealand, vol. 18, pp. 66–71, 1966. View at Google Scholar · View at Scopus
  17. A. Y. Nemet, S. Vinker, I. Bahar, and I. Kaiserman, “The association of keratoconus with immune disorders,” Cornea, vol. 29, no. 11, pp. 1261–1264, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. I. Merdler, A. Hassidim, N. Sorkin, S. Shapira, Y. Gronovich, and Z. Korach, “Keratoconus and allergic diseases among Israeli adolescents between 2005 and 2013,” Cornea, vol. 34, no. 5, pp. 525–529, 2015. View at Publisher · View at Google Scholar
  19. R. Ambrósio Jr., A. L. C. Caiado, F. P. Guerra et al., “Novel pachymetric parameters based on corneal tomography for diagnosing keratoconus,” Journal of Refractive Surgery, vol. 27, no. 10, pp. 753–758, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Ambrósio Jr., I. Ramos, B. Lopes et al., “Assessing ectasia susceptibility prior to LASIK: the role of age and residual stromal bed (RSB) in conjunction to Belin-Ambrósio deviation index (BAD-D),” Revista Brasileira de Oftalmologia, vol. 73, no. 2, pp. 75–80, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. B. L. Kolozsvári, G. Petrovski, P. Gogolák et al., “Association between mediators in the tear fluid and the severity of keratoconus,” Ophthalmic Research, vol. 51, no. 1, pp. 46–51, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Shetty, A. Ghosh, R. R. Lim et al., “Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients is inhibited by cyclosporine A,” Investigative Ophthalmology & Visual Science, vol. 56, no. 2, pp. 738–750, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. S. Rabinowitz, “Videokeratographic indices to aid in screening for keratoconus,” Journal of Refractive Surgery, vol. 11, no. 5, pp. 371–379, 1995. View at Google Scholar · View at Scopus
  24. I. Lema, J. A. Durán, C. Ruiz, E. Díez-Feijoo, A. Acera, and J. Merayo, “Inflammatory response to contact lenses in patients with keratoconus compared with myopic subjects,” Cornea, vol. 27, no. 7, pp. 758–763, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Miháltz, I. Kovács, Á. Takács, and Z. Z. Nagy, “Evaluation of keratometric, pachymetric, and elevation parameters of keratoconic corneas with pentacam,” Cornea, vol. 28, no. 9, pp. 976–980, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. Ö. Ö. Uçakhan, V. Çetinkor, M. Özkan, and A. Kanpolat, “Evaluation of Scheimpflug imaging parameters in subclinical keratoconus, keratoconus, and normal eyes,” Journal of Cataract and Refractive Surgery, vol. 37, no. 6, pp. 1116–1124, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Fodor, B. L. Kolozsvári, G. Petrovski et al., “Effect of contact lens wear on the release of tear mediators in keratoconus,” Eye and Contact Lens, vol. 39, no. 2, pp. 147–152, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. K. E. Clark, H. Lopez, B. A. Abdi et al., “Multiplex cytokine analysis of dermal interstitial blister fluid defines local disease mechanisms in systemic sclerosis,” Arthritis Research and Therapy, vol. 17, article 73, 2015. View at Publisher · View at Google Scholar
  29. B. Mickiewicz, P. Tam, C. N. Jenne et al., “Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit,” Critical Care, vol. 19, no. 1, article 11, 2015. View at Publisher · View at Google Scholar
  30. F. J. Matthews, S. D. Cook, M. A. Majid, A. D. Dick, and V. A. Smith, “Changes in the balance of the tissue inhibitor of matrix metalloproteinases (TIMPs)-1 and -3 may promote keratocyte apoptosis in keratoconus,” Experimental Eye Research, vol. 84, no. 6, pp. 1125–1134, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Sakimoto and M. Sawa, “Metalloproteinases in corneal diseases: degradation and processing,” Cornea, vol. 31, no. 11, pp. S50–S56, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. Z. Mackiewicz, M. Määttä, M. Stenman, L. Konttinen, T. Tervo, and Y. T. Konttinen, “Collagenolytic proteinases in keratoconus,” Cornea, vol. 25, no. 5, pp. 603–610, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. V. Knäuper, L. Bailey, J. R. Worley, P. Soloway, M. L. Patterson, and G. Murphy, “Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13,” FEBS Letters, vol. 532, no. 1-2, pp. 127–130, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. H. R. Lijnen, “Elements of the fibrinolytic system,” Annals of the New York Academy of Sciences, vol. 936, pp. 226–236, 2001. View at Google Scholar · View at Scopus
  35. J.-D. Vassalli, A.-P. Sappino, and D. Belin, “The plasminogen activator/plasmin system,” The Journal of Clinical Investigation, vol. 88, no. 4, pp. 1067–1072, 1991. View at Publisher · View at Google Scholar · View at Scopus
  36. W. Stankiewicz, M. P. Dabrowski, A. Chcialowski, and T. Plusa, “Cellular and cytokine immunoregulation in patients with chronic obstructive pulmonary disease and bronchial asthma,” Mediators of Inflammation, vol. 11, no. 5, pp. 307–312, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. N. A. Hanania, “Targeting airway inflammation in asthma: current and future therapies,” Chest, vol. 133, no. 4, pp. 989–998, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. E. Banach-Wawrzeńczyk, A. Dziedziczko, and D. Rość, “Fibrinolysis system in patients with bronchial asthma,” Medical Science Monitor, vol. 6, no. 1, pp. 103–107, 2000. View at Google Scholar · View at Scopus
  39. Y. Higashimoto, Y. Yamagata, S. Taya et al., “Systemic inflammation in COPD and asthma: similarities and differences,” The Journal of the Japanese Respiratory Society, vol. 46, no. 6, pp. 443–447, 2008. View at Google Scholar · View at Scopus
  40. S. Saad-El-Din Bessa, G. H. Abo El-Magd, and M. M. Mabrouk, “Serum chemokines RANTES and monocyte chemoattractant protein-1 in Egyptian patients with atopic asthma: relationship to disease severity,” Archives of Medical Research, vol. 43, no. 1, pp. 36–41, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. P. Hodsman, C. Ashman, A. Cahn et al., “A phase 1, randomized, placebo-controlled, dose-escalation study of an anti-IL-13 monoclonal antibody in healthy subjects and mild asthmatics,” British Journal of Clinical Pharmacology, vol. 75, no. 1, pp. 118–128, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. K.-Y. Moon, P.-H. Lee, S.-W. Park, C.-S. Park, and A.-S. Jang, “Serum angiopoietin is associated with lung function in patients with asthma: a retrospective cohort study,” BMC Pulmonary Medicine, vol. 14, no. 1, article 143, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. K. Grzela, W. Zagorska, A. Krejner et al., “Prolonged treatment with inhaled corticosteroids does not normalize high activity of Matrix Metalloproteinase-9 in exhaled breath condensates of children with asthma,” Archivum Immunologiae et Therapiae Experimentalis, vol. 63, no. 3, pp. 231–237, 2015. View at Publisher · View at Google Scholar