OM-101 Decreases the Fibrotic Response Associated with Proliferative Vitreoretinopathy

Figure 2

Histological staining (H&E) of induced RD and PVR in retina treated with OM-101. (a) Histological staining (H&E) demonstrated the following: left (control/Hepes), normal architecture; middle (dispase + PBS), abnormal morphology with inflammatory cells, fibroblasts, and pigment stain RPE cells through the retina denoting PVR; and right (dispase + OM 101), OM 101 treatment maintained the normal structure of the retina. Scale bar 100 μm or 200 μm. (b) Number of mice developing RD or PVR. (c) Severity score of the mice retina measured by thickness of the RD, number of inflammatory cells, loss of normal structure, and the appearance of RPE cells inside the retina (). Statistics were computed using Student’s t-test (two-tailed distribution equal variance). Data is expressed as the mean ± SD.

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