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Journal of Ophthalmology
Volume 2017 (2017), Article ID 1847179, 8 pages
Clinical Study

Outcome of Surgical Treatment in Late-Onset Capsular Block Syndrome

1Department of Ophthalmology, The Chinese People’s Liberation Army General Hospital, Beijing, China
2Medical Department, The First Hospital Affiliated to General Hospital of the Chinese People’s Liberation Army, Beijing, China

Correspondence should be addressed to Zhaohui Li

Received 15 January 2017; Revised 3 April 2017; Accepted 18 April 2017; Published 9 July 2017

Academic Editor: Tamer A. Macky

Copyright © 2017 Yang Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To further investigate the pathogenesis of late-onset capsular block syndrome (CBS) and to evaluate the safety of surgical treatment. Methods. Seven patients diagnosed with late-onset CBS were retrospectively analyzed. Anterior chamber depth (ACD), intraocular pressure (IOP), refractive diopter, and best-corrected visual acuity (BCVA) before and after surgery were recorded. The opaque substance was tested with Western blot, and a flow cytometer multiple array assay system was utilized to evaluate the levels of inflammatory cytokines from opaque substance and aqueous humor, respectively. Results. Patients who had undergone surgical treatment showed a significant BCVA and spherical equivalent refractive error improvement (, , resp.). Nevertheless, ACD and IOP before and after surgery were in normal range with no difference (, , resp.). αB-crystallin and βB-crystallin were detected in all opaque substances. Tumor necrosis factor-alpha (TNF-α) and interlukin-1β (IL-1β) levels in opaque substance were significantly higher than those in aqueous humor (, , resp.), while IL-2 and IL-6 were not detected in any samples. Conclusions. Opaque substance is derived from human lens epithelial cells. Inflammatory cytokines may be involved in the pathogenesis of late-onset CBS. In addition, surgical treatment is an effective approach. This trial is registered with ChiCTR-IOR-17011287.