Association of Neovascular Glaucoma with Risk of Stroke: A Population-Based Cohort Study

Table 2

Comparison of the incidence density rates of stroke between patients with NVG and controls stratified by demographic characteristics and comorbidities.

	NVG						Crude HR (95% CI)	Adjusted HR^† (95% CI)
	Yes			No
	Event	PY	Rate^#	Event	PY	Rate^#
All	66	1736	3.80	257	21,658	1.19	3.21 (2.45–4.21)	2.07 (1.41–3.02)
Hemorrhagic stroke	8		0.46	30		0.14	3.24 (1.48–7.08)	1.15 (0.35–3.85)
Ischemic stroke	58		3.34	227		1.05	3.20 (2.40–4.28)	2.24 (1.51–3.32)
Age
≤49	7	470	1.49	9	5561	0.16	9.91 (3.68–26.7)	1.51 (0.22–10.5)
50–64	25	583	4.28	57	7833	0.73	5.71 (3.56–9.17)	3.42 (1.97–5.95)
≥65	34	682	4.98	191	8264	2.31	2.18 (1.51–3.14)	1.83 (1.22–2.74)
Sex
Female	35	735	4.76	103	9763	1.06	4.49 (3.05–6.60)	2.74 (1.63–4.61)
Male	31	1000	3.10	154	11,895	1.29	2.40 (1.63–3.53)	1.66 (0.95–2.89)
Medical comorbidity^&
No	3	367	0.82	55	11,476	0.48	1.67 (0.52–5.35)	1.20 (0.27–5.44)
Yes	63	1368	4.60	202	10,182	1.98	2.34 (1.76–3.11)	2.14 (1.43–3.19)
Ocular comorbidity^§
No	16	606	2.64	245	21,270	1.15	2.29 (1.38–3.80)	1.82 (1.10–3.03)
Yes	50	1130	4.42	12	388	3.09	1.43 (0.76–2.69)	1.93 (1.00–3.75)

^#Incidence rate per 10,000 person-years; crude HR represents relative hazard ratio. ^†Variables that were found to be significant in the univariable analysis and which were included in the multivariable analysis. ^&Medical comorbidity (having at least one comorbidity classified as a medical comorbidity (e.g., diabetes mellitus, hypertension, hyperlipidemia, or coronary artery disease)). ^§Ocular comorbidity (having at least one comorbidity classified as an ocular comorbidity (e.g., central and branch retinal vein occlusion, diabetic retinopathy, retinal detachment with retinal defect, central and branch retinal artery occlusion, hypertensive retinopathy, and uveitis)). , , .