Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems
Optical coherence tomography follow-up after ocriplasmin versus vehicle in the porcine PVD model. (a) Incidence of PVD, subretinal fluid (SRF), and hyperreflective spots (HRS) after administration of vehicle or 96 μg/eye ocriplasmin ( eyes per group). (b–e) Representative OCT images of the retina 5 weeks after treatment with either vehicle (b, d) or ocriplasmin (c, e) in a location-matched retinal region where no PVD was present (b, c) or where PVD was observed (d, e). Left images represent fundus image, middle image shows OCT of the retina, and white inset boxes indicate locations of OCT detail (right images). No disruption of retinal layers is observed.
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