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Journal of Ophthalmology
Volume 2017, Article ID 2340236, 10 pages
Research Article

Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma

1Department of Ophthalmology, Hospital Universitario de Canarias, La Laguna, Spain
2Department of Systems Engineering, University of La Laguna, La Laguna, Spain
3Department of Ophthalmology, University of La Laguna, La Laguna, Spain

Correspondence should be addressed to Manuel Gonzalez de la Rosa; moc.liamg@0591asoraledgm

Received 4 January 2017; Revised 25 April 2017; Accepted 7 May 2017; Published 4 June 2017

Academic Editor: Vital P. Costa

Copyright © 2017 Marta Gonzalez-Hernandez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To observe the relationship between topographic hemoglobin levels in the optic nerve head (ONH), the rim thickness (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness. Methods. 96 normal eyes and 82 glaucomas were examined using TOP strategy (Octopus 300 perimeter), SPECTRALIS OCT, and Laguna ONhE program which estimates hemoglobin from conventional color photographs (Horus Scope DEC 200 fundus camera). Results. The correlation between Laguna ONhE glaucoma discriminant function (GDF) and SPECTRALIS BMO-MRW was (), similar to that between the BMO-MRW and BMO-RNFL thicknesses (, ) ( between both values). GDF correlated well with RNFL thicknesses in the 360 degrees around the nerve, similar to mean perimetric sensitivity (MS) and BMO-MRW. The amount of hemoglobin in the nasal and temporal sectors showed low correlation with superior and inferior RNFL thicknesses. The superotemporal and inferotemporal sectors located on the vertical diameter of the disk showed good intercorrelation but without a clear RNFL topographic relationship. Conclusion. GDF showed high correlation with RNFL thickness. Except in the nasal and temporal sectors, ONH hemoglobin correlated well with RNFL thickness.