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Journal of Ophthalmology
Volume 2017, Article ID 2407037, 7 pages
Review Article

Combination of Anti-VEGF and Laser Photocoagulation for Diabetic Macular Edema: A Review

Vall d’Hebron Hospital, Pg de la Vall d’Hebron 119, 08032 Barcelona, Spain

Correspondence should be addressed to Laura N. Distefano; ten.norbehv@onafetsidnl

Received 5 August 2016; Revised 25 November 2016; Accepted 18 January 2017; Published 27 February 2017

Academic Editor: Raffael Liegl

Copyright © 2017 Laura N. Distefano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diabetic macular edema (DME) is the most common cause of vision loss in diabetic patients. Thirty years ago, the Early Treatment Diabetic Retinopathy Study (ETDRS) demonstrated that focal/grid laser photocoagulation reduces moderate vision loss from DME by 50% or more; thus, macular photocoagulation became the gold standard treatment for DME. However, with the development of anti-VEGF drugs (bevacizumab, ranibizumab, and aflibercept), better outcomes were obtained in terms of visual acuity gain and decrease in macular thickness in some studies when antiangiogenic drugs were administered in monotherapy. Macular laser therapy may still play an important role as an adjuvant treatment because it is able to improve macular thickness outcomes and reduce the number of injections needed. Here, we review some of the clinical trials that have assessed the efficacy of macular laser treatment, either as part of the treatment protocol or as rescue therapy.