A System Review and Meta-Analysis of Canaloplasty Outcomes in Glaucoma Treatment in Comparison with Trabeculectomy

Table 1

Characteristics and baseline information of included literatures.

	Study type	Age, mean (SD)	Male%	Eyes at baseline	POAG%	Baseline IOP,; mean (SD)	Baseline AGMs,; mean (SD)
Canaloplasty standalone
Ayyala et al. [10]	Retrospective	68.3 (10.0)	52	33	NA	21.2 (6.6)	2.5 (0.8)
Barnebey [11]	Retrospective	68.2 (13.1)	55	20	100	23.4 (4.3)	2.2 (1.2)
Brandao et al. [12]	Prospective	71.3 (7.3)	41	19	74	24.6 (5.3)	2.5 (0.8)
Bruggemann and Muller [13]	Retrospective	62.7 (NA)	52	21	100	28.8 (9.6)	2.9 (1.0)
Brusini [14]	Prospective	63.5 (14.0)	NA	214	74	29.4 (7.9)	3.3 (0.9)
Gandolfi et al. [15]	Retrospective	NA	67	24	67	26.0 (4.0)	2.7 (3.3)
Grieshaber et al. [16]	Prospective	49.8 (15.7)	43	60	100	45.0 (12.1)	NA
Grieshaber et al. [17]	Prospective	70.8 (8.4)	49	47	100	26.8 (5.2)	2.8 (0.5)
Grieshaber et al. [18]	Prospective	71.8 (8.8)	41	22	100	27.1 (5.3)	2.9 (0.6)
Kalin-Hajdu et al. [19]	Retrospective	40.0 (19.2)	NA	19	0	30.4 (8.4)	3.7 (0.8)
Lewis et al. [20] (CP)	Prospective	67.6 (11.6)	47	103	89	23.5 (4.5)	1.9 (0.8)
Lommatzsch et al. [7]	Retrospective	40.7 (21.8)	25	14	0	27.1 (12.3)	2.7 (1.1)
Lopes-Cardoso et al. [21] (CP)	Prospective	73.4 (6.0)	66	11	37	24.5 (5.1)	3.4 (0.5)
Matlach et al. [22]	RCT	66.5 (11.3)	60	30	43	23.7 (5.1)	2.6 (1.6)
Matthaei et al. [23] (CP)	Retrospective	65.2 (12.4)	46	33	87	18.5 (6.3)	2.3 (1.2)
Moelle et al. [24]	Retrospective	62 (9)	42	26	54	21.1 (5.8)	2.5 (1.8)
Seuthe et al. [25]	Retrospective	66.7 (11.4)	NA	417	86	20.9 (3.5)	3.5 (0.9)
Thederan et al. [26]	Retrospective	72.9 (5.2)	64	22	68	23.7 (7.6)	3.1 (1.2)
Voykov et al. [27]	Retrospective	60 (11)	45	20	75	25.7 (6.6)	3.4 (0.5)
Wang et al. [28]	Retrospective	39.1 (13.8)	77	17	NA	24.7 (8.7)	2.4 (1.7)
Xin et al. [29]	Prospective	38 (12.8)	65	17	100	29.9 (8.2)	2.9 (0.9)
Canaloplasty with phacoemulsification
Arthur et al. [30]	Retrospective	76.1 (8.3)	56	32	84	18.2 (5.1)	1.3 (0.7)
Lewis et al. [20] (PCP)	Prospective	67.6 (11.6)	47	30	89	23.5 (5.2)	1.5 (1.0)
Lopes-Cardoso et al. [21] (PCP)	Prospective	73.4 (6.0)	66	24	37	19.8 (6.8)	3.3 (0.5)
Matlach et al. [31]	Retrospective	72.9 (5.7)	47	19	47	28.3 (4.1)	2.8 (1.1)
Matthaei et al. [23] (PCP)	Retrospective	65.2 (12.4)	46	13	87	17.5 (4.2)	2.5 (1.3)
Rekas et al. [32]	RCT	74.6 (8.9)	59	29	83	19.0 (6.9)	2.6 (0.7)
Schoenberg et al. [33]	Retrospective	66.8 (8.5)	67	36	94	19.5 (5.7)	NA
Canaloplasty with or without; phacoemulsification, mixed results
Alobeidan and Almobarak [34]	Retrospective	53.4 (15.0)	60	105	67	19.0 (6.7)	2.6 (1.3)
Fujita et al. [35]	Retrospective	71.7 (8.5)	NA	11	100	23.4 (5.5)	2.8 (0.6)
Rekas et al. [36]	Prospective	69.3 (11.4)	40	10	90	19.1 (3.4)	2.2 (1.1)

AGM: antiglaucoma medication; CP: independent canaloplasty subgroup in corresponding literature; NA: data not available; PCP: phacocanaloplasty subgroup in corresponding literature; POAG: primary open-angle glaucoma; RCT: randomized controlled trials.