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Journal of Ophthalmology
Volume 2017 (2017), Article ID 3596817, 9 pages
https://doi.org/10.1155/2017/3596817
Research Article

Clinical Characteristics of Patients with Newly Diagnosed Diabetic Macular Edema in Turkey: A Real-Life Registry Study—TURK-DEM

1Department of Ophthalmology, Hacettepe University Faculty of Medicine, Ankara, Turkey
2Department of Ophthalmology, Gazi University Faculty of Medicine, Ankara, Turkey
3Department of Ophthalmology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey
4Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey
5Bayer Türk, Istanbul, Turkey

Correspondence should be addressed to Bora Eldem; moc.enilnorepus@medleb

Received 3 October 2016; Accepted 19 January 2017; Published 19 February 2017

Academic Editor: Lisa Toto

Copyright © 2017 Bora Eldem et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Varma, N. M. Bressler, Q. V. Doan et al., “Prevalence of and risk factors for diabetic macular edema in the United States,” JAMA Ophthalmology, vol. 132, no. 11, pp. 1334–1340, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Bali and R. T. Bali, “Pathological ocular angiogenesis in diabetes: a perspective of emerging paradigms and current evidence,” Journal of Clinical Ophthalmology and Research, vol. 1, no. 1, pp. 3–10, 2013. View at Publisher · View at Google Scholar
  3. S. Wild, G. Roglic, A. Green, R. Sicree, and H. King, “Global prevalence of diabetes: estimates for the year 2000 and projections for 2030,” Diabetes Care, vol. 27, no. 5, pp. 1047–1053, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. J. E. Shaw, R. A. Sicree, and P. Z. Zimmet, “Global estimates of the prevalence of diabetes for 2010 and 2030,” Diabetes Research and Clinical Practice, vol. 87, no. 1, pp. 4–14, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Studnicka, “The diabetic macular edema – new possibilities of the treatment,” Ceská a Slovenská Oftalmologie, vol. 68, no. 2, pp. 61–63, 2012. View at Google Scholar
  6. R. Klein, B. E. Klein, S. E. Moss, and K. J. Cruickshanks, “The Wisconsin epidemiologic study of diabetic retinopathy. XV. The long-term incidence of macular edema,” Ophthalmology, vol. 102, no. 1, pp. 7–16, 1995. View at Publisher · View at Google Scholar
  7. R. Klein, M. D. Knudtson, K. E. Lee, R. Gangnon, and B. E. Klein, “The Wisconsin epidemiologic study of diabetic retinopathy: XXII the twenty-five-year progression of retinopathy in persons with type 1 diabetes,” Ophthalmology, vol. 115, no. 11, pp. 1859–1868, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Zhang, J. Ma, N. Zhou, B. Zhang, and J. An, “Insulin use and risk of diabetic macular edema in diabetes mellitus: a systemic review and meta-analysis of observational studies,” Medical Science Monitor, vol. 21, pp. 929–936, 2015. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Romero-Aroca, J. Reyes-Torres, M. Baget-Bernaldiz, and C. Blasco-Suñe, “Laser treatment for diabetic macular edema in the 21st century,” Current Diabetes Reviews, vol. 10, no. 2, pp. 100–112, 2014. View at Publisher · View at Google Scholar
  10. J. A. Ford, A. Elders, D. Shyangdan, P. Royle, and N. Waugh, “The relative clinical effectiveness of ranibizumab and bevacizumab in diabetic macular oedema: an indirect comparison in a systematic review,” British Medical Journal, vol. 345, article e5182, 2012. View at Google Scholar
  11. P. Romero-Aroca, “Is laser photocoagulation treatment currently useful in diabetic macular edema?” Medical Hypothesis, Discovery And Innovation in Ophthalmology, vol. 4, no. 1, pp. 5–8, 2015. View at Google Scholar
  12. X. D. Liu, X. D. Zhou, Z. Wang, and H. J. Shen, “Comparison of intravitreal bevacizumab with macular photocoagulation for treatment of diabetic macular edema: a systemic review and meta-analysis,” International Journal of Ophthalmology, vol. 7, no. 6, pp. 1048–1055, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Tas, M. Z. Bayraktar, U. Erdem, G. Sobaci, and M. Ucar, “Prevalence and risk factors for diabetic retinopathy in Turkey,” Gulhane Medical Journal, vol. 47, no. 3, pp. 164–174, 2005, http://www.scopemed.org/?mno=5224Prevalence View at Google Scholar
  14. S. Saturni, F. Bellini, F. Braido et al., “Randomized controlled trials and real life studies. Approaches and methodologies: a clinical point of view,” Pulmonary Pharmacology and Therapeutics, vol. 27, no. 2, pp. 129–138, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Romero-Aroca, J. Fernández-Balart, M. Baget-Bernaldiz et al., “Changes in the diabetic retinopathy epidemiology after 14 years in a population of type 1 and 2 diabetic patients after the new diabetes mellitus diagnosis criteria and a more strict control of the patients,” Journal of Diabetes and its Complications, vol. 23, no. 4, pp. 229–238, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. T. M. Diep and I. Tsui, “Risk factors associated with diabetic macular edema,” Diabetes Research and Clinical Practice, vol. 100, no. 3, pp. 298–305, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Mathew, A. Yunirakasiwi, and S. Sanjay, “Updates in the management of diabetic macular edema,” Journal of Diabetes Research, vol. 2015, Article ID 794036, 8 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. L. P. Aiello, T. W. Gardner, G. L. King et al., “Diabetic retinopathy,” Diabetes Care, vol. 21, no. 1, pp. 143–156, 1998. View at Publisher · View at Google Scholar
  19. J. M. Lopes de Faria, A. E. Jalkh, C. L. Trempe, and J. W. McMeel, “Diabetic macular edema: risk factors and concomitants,” Acta Ophthalmologica Scandinavica, vol. 77, no. 2, pp. 170–175, 1999. View at Publisher · View at Google Scholar
  20. L. P. Aiello, M. T. Cahill, and J. S. Wong, “Systemic considerations in the management of diabetic retinopathy,” American Journal of Ophthalmology, vol. 132, no. 5, pp. 760–776, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. S. J. Song and T. Y. Wong, “Current concepts in diabetic retinopathy,” Diabetes and Metabolism Journal, vol. 38, no. 6, pp. 416–425, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. M. I. Roh, J. H. Kim, and O. W. Kwon, “Features of optical coherence tomography are predictive of visual outcomes after intravitreal bevacizumab injection for diabetic macular edema,” Ophthalmologica, vol. 224, no. 6, pp. 374–380, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Framme, P. Schweizer, M. Imesch, S. Wolf, and U. Wolf-Schnurrbusch, “Behavior of SD-OCT-detected hyperreflective foci in the retina of anti-VEGF-treated patients with diabetic macular edema,” Investigative Ophthalmology and Visual Science, vol. 53, no. 9, pp. 5814–5818, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Shimura, K. Yasuda, M. Yasuda, and T. Nakazawa, “Visual outcome after intravitreal bevacizumab depends on the optical coherence tomographic patterns of patients with diffuse diabetic macular edema,” Retina, vol. 33, no. 4, pp. 740–747, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. B. Mushtaq, N. J. Crosby, A. T. Dimopoulos et al., “Effect of initial retinal thickness on outcome of intravitreal bevacizumab therapy for diabetic macular edema,” Clinical Ophthalmology, vol. 8, pp. 807–812, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Kakinoki, T. Miyake, O. Sawada, T. Sawada, H. Kawamura, and M. Ohji, “Comparison of macular thickness in diabetic macular edema using spectral-domain optical coherence tomography and time-domain optical coherence tomography,” Journal of Ophthalmology, vol. 2012, Article ID 959721, 5 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Lammer, C. Scholda, C. Prünte, T. Benesch, U. Schmidt-Erfurth, and M. Bolz, “Retinal thickness and volume measurements in diabetic macular edema: a comparison of four optical coherence tomography systems,” Retina, vol. 31, no. 1, pp. 48–55, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. F. Forooghian, C. Cukras, C. B. Meyerle, E. Y. Chew, and W. T. Wong, “Evaluation of time domain and spectral domain optical coherence tomography in the measurement of diabetic macular edema,” Investigative Ophthalmology and Visual Science, vol. 49, no. 10, pp. 4290–4296, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Mitchell, F. Bandello, U. Schmidt-Erfurth et al., “The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema,” Ophthalmology, vol. 118, no. 4, pp. 615–625, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. Diabetic Retinopathy Clinical Research Network, M. J. Elman, L. P. Aiello et al., “Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema,” Ophthalmology, vol. 117, no. 6, pp. 1064–1077, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. D. J. Browning, M. M. Altaweel, N. M. Bressler, S. B. Bressler, I. U. Scott, and Diabetic Retinopathy Clinical Research Network, “Diabetic macular edema: what is focal and what is diffuse?” American Journal of Ophthalmology, vol. 146, no. 5, pp. 649–655, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Ophir, R. Hanna, and M. R. Martinez, “Importance of 3-D image reconstruction of spectral-domain OCT on outcome of grid laser photocoagulation for diffuse diabetic macular edema,” International Journal of Ophthalmology, vol. 6, no. 6, pp. 836–843, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. M. S. Blumenkranz, “Optimal current and future treatments for diabetic macular oedema,” Eye, vol. 24, no. 3, pp. 428–434, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. Early Treatment Diabetic Retinopathy Study research group, “Photocoagulation for diabetic macular edema. Early treatment diabetic retinopathy study report number 1,” Archives of Ophthalmology, vol. 103, no. 12, pp. 1796–1806, 1985. View at Publisher · View at Google Scholar · View at Scopus
  35. A. J. Augustin, “Upcoming therapeutic advances in diabetic macular edema: an intravitreal dexamethasone drug delivery system,” Expert Opinion on Drug Delivery, vol. 8, no. 2, pp. 271–279, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. P. Massin, F. Bandello, J. G. Garweg et al., “Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE study): a 12-month, randomized, controlled, double-masked, multicenter phase II study,” Diabetes Care, vol. 33, no. 11, pp. 2399–2405, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Michaelides, A. Kaines, R. D. Hamilton et al., “A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2,” Ophthalmology, vol. 117, no. 6, pp. 1078–1086, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. D. V. Do, U. Schmidt-Erfurth, V. H. Gonzalez et al., “The DA VINCI study: phase 2 primary results of VEGF trap-eye in patients with diabetic macular edema,” Ophthalmology, vol. 118, no. 9, pp. 1819–1826, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. Q. D. Nguyen, D. M. Brown, D. M. Marcus et al., “Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE,” Ophthalmology, vol. 119, no. 4, pp. 789–801, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Barteselli, I. Kozak, S. El-Emam, J. Chhablani, M. A. Cortes, and W. R. Freeman, “12-month results of the standardised combination therapy for diabetic macular oedema: intravitreal bevacizumab and navigated retinal photocoagulation,” The British Journal of Ophthalmology, vol. 98, no. 8, pp. 1036–1041, 2014. View at Publisher · View at Google Scholar · View at Scopus