Tissue Distribution of trans-Resveratrol and Its Metabolites after Oral Administration in Human Eyes
Table 2
Concentrations of resveratrol and its major metabolites in the tissues of eyes.
Species
Mean ± SD or N (%)
Conjunctiva (nmol/g)
Aqueous humor (nmol/L)
Vitreous humor (nmol/L)
Resveratrol
17.19 ± 15.32
(0.97–45.12)
Bod
Bod
Resveratrol-3-O-glucuronide
2.32 ± 2.00
86.11 ± 30.76
(0.46–6.85)
(58.44–119.24)
Bod
Resveratrol-4′-O-glucuronide
2.12 ± 2.09
85.17 ± 56.73
(0.35–7.14)
(14.40–148.46)
Bod
Resveratrol-3-sulfate
22.31 ± 24.18
364.9 ± 523.94
62.95 ± 41.97
(1.20–76.65)
(23.38–1503.76)
(22.75–128.20)
Note: values are the mean ± SD of the samples from 35 eyes. Range is in brackets. N, the number of samples which could be quantitated; Bod, below the limit of detection.