Research Article

Tissue Distribution of trans-Resveratrol and Its Metabolites after Oral Administration in Human Eyes

Table 2

Concentrations of resveratrol and its major metabolites in the tissues of eyes.

SpeciesMean ± SD or N (%)
Conjunctiva (nmol/g)Aqueous humor (nmol/L)Vitreous humor (nmol/L)

Resveratrol17.19 ± 15.32
(0.97–45.12)BodBod

Resveratrol-3-O-glucuronide2.32 ± 2.0086.11 ± 30.76
(0.46–6.85)(58.44–119.24)Bod

Resveratrol-4′-O-glucuronide2.12 ± 2.0985.17 ± 56.73
(0.35–7.14)(14.40–148.46)Bod

Resveratrol-3-sulfate22.31 ± 24.18364.9 ± 523.9462.95 ± 41.97
(1.20–76.65)(23.38–1503.76)(22.75–128.20)

Note: values are the mean ± SD of the samples from 35 eyes. Range is in brackets. N, the number of samples which could be quantitated; Bod, below the limit of detection.