The Effect of CM082, an Oral Tyrosine Kinase Inhibitor, on Experimental Choroidal Neovascularization in Rats

Figure 6

Histology of CNV lesions stained with hematoxylin-eosin of the CM082 (30 mg/kg) group () and the corresponding dose of the vehicle group () was obtained after FFA examination. Results showed that administration of CM082 reduces laser-induced CNV lesions. (a) In the vehicle-treated group, CNV formed and broke the Brunch’s membrane. The depigmentation in RPE, aggregation of macrophage, and neovascularization were obtained 14 days and 21 days after photocoagulation. (b) In the CM082 group, the edema, depigmentation, and CNV areas significantly decreased comparing to vehicle-treated group at the same time point. Scale bar, 100 μm.