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Journal of Ophthalmology
Volume 2017 (2017), Article ID 6906139, 7 pages
https://doi.org/10.1155/2017/6906139
Research Article

A Rabbit Model Study to Determine the Efficacy of a Prototype Corneal Endothelium Protector during Cataract Surgery

1Singapore National Eye Centre, Singapore
2Singapore Eye Research Institute, Singapore
3Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Correspondence should be addressed to Shamira Perera; moc.liamtoh@arereparimahs

Received 6 September 2016; Revised 16 November 2016; Accepted 23 November 2016; Published 29 March 2017

Academic Editor: Tamer A. Macky

Copyright © 2017 Annabel C. Y. Chew et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. We evaluated the efficacy and safety of a mechanical device, the P-chute, in corneal endothelium preservation during phacoemulsification in a rabbit model. Methods. Twenty-four rabbits were randomly assigned into 2 groups. One eye of each rabbit underwent phacoemulsification that simulated the removal of a dense nucleus, with or without the P-chute. Serial slit-lamp examinations, anterior segment optical coherence tomography (ASOCT) scans, and specular microscopy were performed. Three rabbits from each group were sacrificed on postoperative days (PODs) 1, 5, 7, and 14. Histological analysis of the corneas was performed. Results. There was a trend towards lesser endothelial cell loss for the P-chute group at POD1 (4.9% versus 12.5%, ), POD5 (10.4% versus 12.2%, ), and POD7 (10.5% versus 17.2%, ). There was no significant difference in the corneal thickness () between the 2 groups. The insertion of the device was challenging. The use of the P-chute only added an extra 15% to the surgical time. Conclusions. There was a trend towards better endothelium preservation with the P-chute even though the results were not statistically significant. We believe that the device could be useful in certain surgical situations. Further work is needed to improve the device insertion.