Additive Intraocular Pressure-Lowering Effects of Ripasudil with Glaucoma Therapeutic Agents in Rabbits and Monkeys
Additive IOP-lowering effect of ripasudil with nipradilol. Rabbits were administered vehicle (○), 0.4% ripasudil (●), 0.25% nipradilol (△), or 0.4% ripasudil + 0.25% nipradilol (◆) into one eye (). IOP were measured 0.5, 1, 2, 3, 4, and 5 h after instillation. For combined use of ophthalmic agents, 0.25% nipradilol was administered 5 min after instillation of 0.4% ripasudil. All data are presented as means ± SEs. , compared with vehicle (Tukey’s multiple comparison test).
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