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Journal of Ophthalmology
Volume 2017 (2017), Article ID 7174540, 5 pages
Research Article

Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography Study

1Ophthalmology Department, Asociación para Evitar la Ceguera en México IAP, Mexico City, Mexico
2Retina Department, Asociación para Evitar la Ceguera en México IAP, Mexico City, Mexico

Correspondence should be addressed to Guillermo Salcedo-Villanueva; moc.liamg@allivodeclas

Received 28 July 2017; Revised 16 September 2017; Accepted 25 September 2017; Published 9 October 2017

Academic Editor: Giuseppe Querques

Copyright © 2017 David Berrones et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To describe changes in the retina and choroidal flow by optical coherence tomography angiography (OCT-A) after a single dose of oral sildenafil. Method. A case-control study. Patients in the study group received 50 mg of oral sildenafil. Patients in the control group received a sham pill. Retinal and choroidal images were obtained at baseline (before pill ingestion) and 1 hour after ingestion. Central macular and choroidal thickness, choroidal and outer retina flow, and the retinal and choroidal vascular density were compared using a Mann-Whitney U test. Results. Twenty eyes were enrolled into the study group and 10 eyes in the control group. There was a significant difference in central choroidal thickness and outer retina blood flow between groups after 1 hour of sildenafil ingestion (). There were no differences in central macular thickness, choroidal flow, and retinal vascular density among groups. Conclusions. A single dose of oral sildenafil increases choroidal thickness, probably due to sildenafil-induced vasodilation.